SRD5A2

SRD5A2
Identifiers
Aliases SRD5A2, entrez:6716
External IDs OMIM: 607306 MGI: 2150380 HomoloGene: 37292 GeneCards: SRD5A2
Targeted by Drug
finasteride[1]
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

6716

94224

Ensembl

ENSG00000277893

ENSMUSG00000038541

UniProt

P31213

Q99N99

RefSeq (mRNA)

NM_000348

NM_053188

RefSeq (protein)

NP_000339.2

NP_444418.1

Location (UCSC) Chr 2: 31.52 – 31.58 Mb Chr 17: 74.02 – 74.05 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

3-oxo-5-alpha-steroid 4-dehydrogenase 2 is an enzyme that in humans is encoded by the SRD5A2 gene.[4][5]

Steroid 5-alpha reductase catalyzes the conversion of the male sex hormone testosterone into the more potent androgen, dihydrotestosterone.

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).[5]

See also

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the 11/22/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.