APOBEC3H

APOBEC3H
Identifiers
Aliases APOBEC3H, A3H, ARP-10, ARP10, apolipoprotein B mRNA editing enzyme catalytic subunit 3H
External IDs HomoloGene: 52306 GeneCards: APOBEC3H
Orthologs
Species Human Mouse
Entrez

164668

n/a

Ensembl

ENSG00000100298

n/a

UniProt

Q6NTF7

n/a

RefSeq (mRNA)

NM_001166002
NM_001166003
NM_001166004
NM_181773

n/a

RefSeq (protein)

NP_001159474.2
NP_001159475.2
NP_001159476.2
NP_861438.3

n/a

Location (UCSC) Chr 22: 39.1 – 39.1 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

DNA dC->dU-editing enzyme APOBEC-3H, also known as Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H or APOBEC-related protein 10, is a protein that in humans is encoded by the APOBEC3H gene.[2]

Function

This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide (APOBEC) family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistance to human immunodeficiency virus type 1 infection in certain populations. There are only one to two members of this family of genes in nonprimate mammals but at least seven members in primates. APOBEC3H is an antiviral effector. In Old world monkeys APOBEC3H has efficient antiviral activity against primate lentiviruses and it is sensitive to inactivation by the simian immunodeficiency virus Vif protein, and is capable of hypermutating retroviral genomes. The typical human APOBEC3H gene is inherently poorly expressed in primate cells and is ineffective at inhibiting retroviral replication.[3] Importantly, different people have different strengths and potencies of APOBEC3H. People with version of the gene for APOBEC3H which produce stable variations of the protein can successfully limited HIV-1's ability to replicate.[4]

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Entrez Gene: apolipoprotein B mRNA editing enzyme".
  3. ↑ OhAinle M, Kerns JA, Malik HS, Emerman M (2006). "Adaptive evolution and antiviral activity of the conserved mammalian cytidine deaminase APOBEC3H". J. Virol. 80 (8): 3853–62. doi:10.1128/JVI.80.8.3853-3862.2006. PMC 1440450Freely accessible. PMID 16571802.
  4. ↑ Refsland EW, Hultquist JF, Luengas EM, Ikeda T, Shaban NM, Law EK, Brown WL, Reilly C, Emerman M, Harris RS (2014). "Natural Polymorphisms in Human APOBEC3H and HIV-1 Vif Combine in Primary T Lymphocytes to Affect Viral G-to-A Mutation Levels and Infectivity". PLoS Genet. 10 (11): e1004761. doi:10.1371/journal.pgen.1004761. PMC 4238949Freely accessible. PMID 25411794.

Further reading

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