ARHGAP18

Rho GTPase activating protein 18 is a protein that in humans is encoded by the ARHGAP18 gene.[1] The gene is also known as MacGAP and bA307O14.2.[1] ARHGAP18 belongs to a family of Rho GTPase-activating proteins that modulate cell signaling.[2]

Model organisms

Model organisms have been used in the study of ARHGAP18 function. A conditional knockout mouse line, called Arhgap18tm1a(KOMP)Wtsi[7][8] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[9][10][11]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[5][12] Twenty three tests were carried out on mutant mice and one significant abnormality was observed.[5] Fewer than expected homozygous mutant embryos were identified during gestation.[5]

References

  1. 1 2 "Rho GTPase activating protein 18". Retrieved 2011-12-05.
  2. ↑ Potkin, S. G.; Turner, J. A.; Fallon, J. A.; Lakatos, A.; Keator, D. B.; Guffanti, G.; MacCiardi, F. (2008). "Gene discovery through imaging genetics: Identification of two novel genes associated with schizophrenia". Molecular Psychiatry. 14 (4): 416–428. doi:10.1038/mp.2008.127. PMC 3254586Freely accessible. PMID 19065146.
  3. ↑ "Salmonella infection data for Arhgap18". Wellcome Trust Sanger Institute.
  4. ↑ "Citrobacter infection data for Arhgap18". Wellcome Trust Sanger Institute.
  5. 1 2 3 4 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  6. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  7. ↑ "International Knockout Mouse Consortium".
  8. ↑ "Mouse Genome Informatics".
  9. ↑ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750.
  10. ↑ Dolgin E (2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  11. ↑ Collins FS, Rossant J, Wurst W (2007). "A Mouse for All Reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  12. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353.

Further reading


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