ASF1A

ASF1A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ASF1A, CGI-98, CIA, HSPC146, anti-silencing function 1A histone chaperone
External IDs MGI: 1913653 HomoloGene: 8528 GeneCards: ASF1A
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

25842

66403

Ensembl

ENSG00000111875

ENSMUSG00000019857

UniProt

Q9Y294

Q9CQE6

RefSeq (mRNA)

NM_014034

NM_025541

RefSeq (protein)

NP_054753.1

NP_079817.1

Location (UCSC) Chr 6: 118.89 – 118.91 Mb Chr 10: 53.6 – 53.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Histone chaperone ASF1A is a protein that in humans is encoded by the ASF1A gene.[3][4][5]

Function

This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.[5]

Interactions

ASF1A has been shown to interact with TLK1,[6][7] TLK2,[6] CHAF1B[8] and CHAF1A.[8]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (May 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Research. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876Freely accessible. PMID 10810093.
  4. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Oct 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934Freely accessible. PMID 11042152.
  5. 1 2 "Entrez Gene: ASF1A ASF1 anti-silencing function 1 homolog A (S. cerevisiae)".
  6. 1 2 Silljé HH, Nigg EA (Jul 2001). "Identification of human Asf1 chromatin assembly factors as substrates of Tousled-like kinases". Current Biology. 11 (13): 1068–73. doi:10.1016/S0960-9822(01)00298-6. PMID 11470414.
  7. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  8. 1 2 Mello JA, Silljé HH, Roche DM, Kirschner DB, Nigg EA, Almouzni G (Apr 2002). "Human Asf1 and CAF-1 interact and synergize in a repair-coupled nucleosome assembly pathway". EMBO Reports. 3 (4): 329–34. doi:10.1093/embo-reports/kvf068. PMC 1084056Freely accessible. PMID 11897662.

Further reading

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