ATG4B

ATG4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases ATG4B, APG4B, AUTL1, autophagy related 4B cysteine peptidase
External IDs MGI: 1913865 HomoloGene: 100868 GeneCards: ATG4B
Orthologs
Species Human Mouse
Entrez

23192

66615

Ensembl

ENSG00000168397

ENSMUSG00000026280

UniProt

Q9Y4P1

Q8BGE6

RefSeq (mRNA)

NM_013325
NM_178326

NM_174874

RefSeq (protein)

NP_037457.3
NP_847896.1

NP_777363.1

Location (UCSC) Chr 2: 241.64 – 241.67 Mb Chr 1: 93.75 – 93.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Cysteine protease ATG4B is an enzyme that in humans is encoded by the ATG4B gene.[3][4]

Function

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[4] One main function of Atg4 is to cleave the pre-protein of Atg8, leading to the non-lapidated soluble (-I) form which can be processed further by Atg3, Atg7, Atg5-12 into the lipidated form (-II) anchored to the autophagic membrane.

Interactions

ATG4B has been shown to interact with GABARAPL2.[5][6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Mariño G, Uría JA, Puente XS, Quesada V, Bordallo J, López-Otín C (Feb 2003). "Human autophagins, a family of cysteine proteinases potentially implicated in cell degradation by autophagy". The Journal of Biological Chemistry. 278 (6): 3671–8. doi:10.1074/jbc.M208247200. PMID 12446702.
  4. 1 2 "Entrez Gene: ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae)".
  5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948Freely accessible. PMID 17353931.
  6. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

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