ATP6V0C

ATP6V0C
Identifiers
Aliases	ATP6V0C, ATP6C, ATP6L, ATPL, VATL, VPPC, Vma3, ATPase H+ transporting V0 subunit c
External IDs	MGI: 88116 HomoloGene: 68199 GeneCards: ATP6V0C
Gene ontology Molecular function • proton-transporting ATP synthase activity, rotational mechanism • proton-transporting ATPase activity, rotational mechanism • protein binding • hydrogen ion transmembrane transporter activity • ubiquitin protein ligase binding Cellular component • integral component of membrane • proton-transporting V-type ATPase, V0 domain • phagocytic vesicle membrane • proton-transporting two-sector ATPase complex, proton-transporting domain • membrane • vacuolar membrane • focal adhesion • vacuolar proton-transporting V-type ATPase, V0 domain • lysosomal membrane • vacuole • endosome membrane • extracellular exosome Biological process • insulin receptor signaling pathway • lysosomal lumen acidification • transferrin transport • ion transport • proton transport • positive regulation of Wnt signaling pathway • ion transmembrane transport • transport • viral process • ATP hydrolysis coupled proton transport • regulation of macroautophagy • phagosome acidification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	527	11984
Ensembl	ENSG00000185883	ENSMUSG00000024121
UniProt	P27449	P63082
RefSeq (mRNA)	NM_001694 NM_001198569	NM_009729
RefSeq (protein)	NP_001185498.1 NP_001685.1	NP_033859.1
Location (UCSC)	Chr 16: 2.51 – 2.52 Mb	Chr 17: 24.16 – 24.17 Mb
PubMed search	[1]	[2]
Wikidata

V-type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0C gene.^[3][4][5]

Function

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L.^[5]

References

Further reading