Agonist-antagonist
In pharmacology the term agonist–antagonist or mixed agonist/antagonist is used to refer to a drug which under some conditions behaves as an agonist (a substance that fully activates the receptor that it binds to) while under other conditions, behaves as an antagonist (a substance that binds to a receptor but does not activate and can block the activity of other agonists).
Types of mixed agonist/antagonist include receptor ligands that act as agonist for some receptor types and antagonist for others or agonist in some tissues while antagonist in others (also known as selective receptor modulators).
Agonist–antagonist opioids
The best known agonist–antagonists are opioids. Examples of such opioids are:
A pure opioid antagonist used in medicine is naloxone (not to be confused with naltrexone).
Agonist–antagonist opioids usually have a ceiling effect – over particular dose they don't increase their potency.
Some preparations of buprenorphine (e.g. Suboxone, in contrast to Subutex) contain naloxone in order to deter intravenous injection (oral naloxone is almost inactive) – it is not related to agonist–antagonist concept.