Aprindine

Aprindine
Clinical data

AHFS/Drugs.com	International Drug Names
ATC code	C01BB04 (WHO)
Identifiers
IUPAC name {3-[2,3-dihydro-1H-inden-2-yl(phenyl)amino]propyl}diethylamine
CAS Number	37640-71-4^Y
PubChem (CID)	2218
DrugBank	DB01429^Y
ChemSpider	2132^Y
UNII	5Y48085P9Q^Y
KEGG	D02969^Y
ChEMBL	CHEMBL1213033^Y
Chemical and physical data
Formula	C₂₂H₃₀N₂
Molar mass	322.487 g/mol
3D model (Jmol)	Interactive image
SMILES c1cccc3c1CC(N(c2ccccc2)CCCN(CC)CC)C3
InChI InChI=1S/C22H30N2/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3^Y Key:NZLBHDRPUJLHCE-UHFFFAOYSA-N^Y
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Aprindine is a Class 1b antiarrhythmic agent.^[1]

In one study, it delayed atrial fibrillation more than digoxin did.^[2]

It has shown effectiveness when given orally.^[3]

References

↑ Sato R, Hisatome I, Tanaka Y, et al. (September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol. 344 (3): 331–6. doi:10.1007/bf00183008. PMID 1660104.
↑ Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation". Circ. J. 66 (6): 553–6. doi:10.1253/circj.66.553. PMID 12074271.
↑ Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff-Parkinson-White syndrome". Br Heart J. 39 (12): 1353–60. doi:10.1136/hrt.39.12.1353. PMC 483421. PMID 603737.

class Ia (Phase 0→ and Phase 3→)	Ajmaline Disopyramide Lorajmine Prajmaline Procainamide^# Quinidine^# Sparteine

class Ib (Phase 3←)	IV (Lidocaine^#) enteral (Aprindine Mexiletine Tocainide)

class Ic (Phase 0→)	Encainide^‡ Ethacizine Flecainide Indecainide^‡ Lorcainide Moracizine^‡ Propafenone

class II (Phase 4→, β blockers)	Nadolol Pindolol Propranolol cardioselective (Acebutolol Atenolol Esmolol Metoprolol)

A₁ agonist	Adenosine Benzodiazepines Barbiturates

M₂	muscarinic antagonist: Atropine Disopyramide Quinidine muscarinic agonist: Digoxin

α receptors	Amiodarone Bretylium Quinidine Verapamil

Na⁺/ K⁺-ATPase	Digoxin

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