BAALC

brain and acute leukemia, cytoplasmic
Identifiers
Symbol BAALC
Entrez 79870
HUGO 14333
OMIM 606602
RefSeq NP_079088.1&rn=1 NP_001019543.1 NP_079088.1
UniProt Q8WXS3
Other data
Locus Chr. 8 q22.3

BAALC (Brain and Acute Leukemia, Cytoplasmic)is a gene that has been associated with acute myeloid leukemia.[1] The gene is conserved among mammals and is not found in lower organisms.[2][3] Tissues that express this gene develop from the neuroectoderm.[2] Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene; however, some of the transcript variants are found only in AML cell lines.[2] Among patients with acute myeloid leukemia, those overexpressing BAALC show distinctly poor prognosis, pointing to a key role of the BAALC products in leukemia.[3] Some sources suggest that BAALC is a gene implicated in both neuroectodermal and hematopoietic cell functions.[3]

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