BBSome

The BBSome is a component of the basal body and is involved in formation of the primary cilium.[1][2] The BBSome is a complex of seven Bardet–Biedl syndrome (BBS) proteins: BBS1, BBS2, BBS4, BBS5, BBS7, BBS8 and BBS9. In addition the BBSome contains the BBIP10 protein.[3]

History

The BBSome was first identified in 2007 by Peter K. Jackson and colleagues.[4]

Assembly

BBSome assembly has been shown to be mediated by a complex containing a further three BBS proteins: BBS6, BBS10 and BBS12. In addition chaperonins of the CCT/TRiC family are involved.[5]

References

  1. Sheffield VC (2010). "The blind leading the obese: the molecular pathophysiology of a human obesity syndrome". Trans. Am. Clin. Climatol. Assoc. 121: 172–81; discussion 181–2. PMC 2917141Freely accessible. PMID 20697559.
  2. Jin H, White SR, Shida T, et al. (June 2010). "The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia". Cell. 141 (7): 1208–19. doi:10.1016/j.cell.2010.05.015. PMC 2898735Freely accessible. PMID 20603001.
  3. Jin H, Nachury MV (June 2009). "The BBSome". Curr. Biol. 19 (12): R472–3. doi:10.1016/j.cub.2009.04.015. PMID 19549489.
  4. Nachury MV, Loktev AV, Zhang Q, et al. (June 2007). "A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis". Cell. 129 (6): 1201–13. doi:10.1016/j.cell.2007.03.053. PMID 17574030.
  5. Seo S, Baye LM, Schulz NP, et al. (January 2010). "BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly". Proc. Natl. Acad. Sci. U.S.A. 107 (4): 1488–93. doi:10.1073/pnas.0910268107. PMC 2824390Freely accessible. PMID 20080638.


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