CD49c

ITGA3
Identifiers
Aliases ITGA3, CD49C, GAP-B3, GAPB3, ILNEB, MSK18, VCA-2, VL3A, VLA3a, FRP-2, integrin subunit alpha 3
External IDs OMIM: 605025 MGI: 96602 HomoloGene: 21129 GeneCards: ITGA3
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

3675

16400

Ensembl

ENSG00000005884

ENSMUSG00000001507

UniProt

P26006

Q62470

RefSeq (mRNA)

NM_002204
NM_005501

NM_013565
NM_001306071
NM_001306162

RefSeq (protein)

NP_002195.1

NP_001293000.1
NP_001293091.1
NP_038593.1

Location (UCSC) Chr 17: 50.06 – 50.09 Mb Chr 11: 95.04 – 95.08 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene.[3][4] ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular matrix proteins.

Alternative names

The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').[5]

Interactions

CD49c has been shown to interact with:

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ Takada Y, Murphy E, Pil P, Chen C, Ginsberg MH, Hemler ME (October 1991). "Molecular cloning and expression of the cDNA for alpha 3 subunit of human alpha 3 beta 1 (VLA-3), an integrin receptor for fibronectin, laminin, and collagen". J Cell Biol. 115 (1): 257–66. doi:10.1083/jcb.115.1.257. PMC 2289928Freely accessible. PMID 1655803.
  4. ↑ Jones SD, van der Flier A, Sonnenberg A (September 1998). "Genomic organization of the human alpha 3 integrin subunit gene". Biochem Biophys Res Commun. 248 (3): 896–8. doi:10.1006/bbrc.1998.9071. PMID 9704023.
  5. ↑ "Entrez Gene: ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)".
  6. ↑ Park KR, Inoue T, Ueda M, Hirano T, Higuchi T, Maeda M, Konishi I, Fujiwara H, Fujii S (March 2000). "CD9 is expressed on human endometrial epithelial cells in association with integrins alpha(6), alpha(3) and beta(1)". Mol. Hum. Reprod. 6 (3): 252–7. doi:10.1093/molehr/6.3.252. PMID 10694273.
  7. ↑ Hirano T, Higuchi T, Ueda M, Inoue T, Kataoka N, Maeda M, Fujiwara H, Fujii S (February 1999). "CD9 is expressed in extravillous trophoblasts in association with integrin alpha3 and integrin alpha5". Mol. Hum. Reprod. 5 (2): 162–7. doi:10.1093/molehr/5.2.162. PMID 10065872.
  8. ↑ Wixler V, Geerts D, Laplantine E, Westhoff D, Smyth N, Aumailley M, Sonnenberg A, Paulsson M (October 2000). "The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes". J. Biol. Chem. 275 (43): 33669–78. doi:10.1074/jbc.M002519200. PMID 10906324.
  9. ↑ Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (July 2000). "Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis". J. Cell. Sci. 113 (13): 2385–97. PMID 10852818.
  10. ↑ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". J. Biol. Chem. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.

Further reading

External links


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