CGB1
Choriogonadotropin subunit beta variant 1 is a protein that in humans is encoded by the CGB1 gene.[2][3]
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID 8954017). However, a 155 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[3]
References
Further reading
- Bo M, Boime I (1992). "Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo.". J. Biol. Chem. 267 (5): 3179–84. PMID 1371113.
- Policastro PF, Daniels-McQueen S, Carle G, Boime I (1986). "A map of the hCG beta-LH beta gene cluster.". J. Biol. Chem. 261 (13): 5907–16. PMID 2422163.
- Jameson JL, Lindell CM (1989). "Isolation and characterization of the human chorionic gonadotropin beta subunit (CG beta) gene cluster: regulation of transcriptionally active CG beta gene by cyclic AMP.". Mol. Cell. Biol. 8 (12): 5100–7. PMC 365611
. PMID 2468994.
- Julier C, Weil D, Couillin P, et al. (1984). "The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19.". Hum. Genet. 67 (2): 174–7. doi:10.1007/BF00272995. PMID 6204923.
- Talmadge K, Boorstein WR, Vamvakopoulos NC, et al. (1985). "Only three of the seven human chorionic gonadotropin beta subunit genes can be expressed in the placenta.". Nucleic Acids Res. 12 (22): 8415–36. doi:10.1093/nar/12.22.8415. PMC 320381. PMID 6209613.
- Talmadge K, Boorstein WR, Fiddes JC (1984). "The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone.". DNA. 2 (4): 281–9. doi:10.1089/dna.1983.2.281. PMID 6319099.
- Talmadge K, Vamvakopoulos NC, Fiddes JC (1984). "Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.". Nature. 307 (5946): 37–40. doi:10.1038/307037a0. PMID 6690982.
- Dirnhofer S, Hermann M, Hittmair A, et al. (1997). "Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1.". J. Clin. Endocrinol. Metab. 81 (12): 4212–7. doi:10.1210/jc.81.12.4212. PMID 8954017.
- Venter JC, Adams MD, Myers EW, et al. (2001). "The sequence of the human genome.". Science. 291 (5507): 1304–51. doi:10.1126/science.1058040. PMID 11181995.
- Giovangrandi Y, Parfait B, Asheuer M, et al. (2001). "Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays.". Cancer Lett. 168 (1): 93–100. doi:10.1016/S0304-3835(01)00496-7. PMID 11368883.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Hallast P, Rull K, Laan M (2007). "The evolution and genomic landscape of CGB1 and CGB2 genes.". Mol. Cell. Endocrinol. 260-262: 2–11. doi:10.1016/j.mce.2005.11.049. PMC 2599907. PMID 17055150.
PDB gallery |
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| 1hcn: STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN AT 2.6 ANGSTROMS RESOLUTION FROM MAD ANALYSIS OF THE SELENOMETHIONYL PROTEIN |
| 1hrp: CRYSTAL STRUCTURE OF HUMAN CHORIONIC GONADOTROPIN |
| 1qfw: TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT |
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