CHRNA6
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Cholinergic receptor, nicotinic, alpha 6, also known as CHRNA6, is a human gene,[4] which codes for the α6 subunit found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain,[5] and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine.[6][7][8] Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.[9][10]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
Nicotine Activity on Dopaminergic Neurons edit
- ↑ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".
See also
References
- ↑ "Drugs that physically interact with Neuronal acetylcholine receptor subunit alpha-6 view/edit references on wikidata".
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- ↑ "Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6".
- ↑ Meyer EL, Yoshikami D, McIntosh JM (2008). "The Neuronal Nicotinic Acetylcholine Receptors α4* and α6* Differentially Modulate Dopamine Release in Mouse Striatal Slices". Journal of Neurochemistry. 105 (5): 1761–9. doi:10.1111/j.1471-4159.2008.05266.x. PMC 2527994
. PMID 18248619. - ↑ Calabresi P, Massimiliano D (Oct 2008). "ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for α6-Containing Nicotinic Receptors?". Neuron. 60 (1): 4–7. doi:10.1016/j.neuron.2008.09.031. PMID 18940582.
- ↑ Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, Bupp S, Heintz N, et al. (2008). "In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors". Neuron. 60 (1): 123–36. doi:10.1016/j.neuron.2008.09.009. PMC 2632732. PMID 18940593.
- ↑ Exley R, Clements MA, Hartung H, McIntosh JM, Cragg SJ (2008). "Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens". Neuropsychopharmacology. 33 (9): 2158–66. doi:10.1038/sj.npp.1301617. PMID 18033235.
- ↑ Quik M, McIntosh JM (2006). "Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy". The Journal of Pharmacology and Experimental Therapeutics. 316 (2): 481–9. doi:10.1124/jpet.105.094375. PMID 16210393.
- ↑ Bordia T, Grady SR, McIntosh JM, Quik M (2007). "Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum". Molecular Pharmacology. 72 (1): 52–61. doi:10.1124/mol.107.035998. PMID 17409284.
Further reading
- Zeiger JS, Haberstick BC, Schlaepfer I, et al. (2008). "The neuronal nicotinic receptor subunit genes (CHRNA6 and CHRNB3) are associated with subjective responses to tobacco". Hum. Mol. Genet. 17 (5): 724–34. doi:10.1093/hmg/ddm344. PMID 18055561.
- Shi J, Hattori E, Zou H, et al. (2007). "No Evidence for Association between 19 Cholinergic Genes and Bipolar Disorder". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144 (6): 715–23. doi:10.1002/ajmg.b.30417. PMC 2576477. PMID 17373692.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Keiger CJ, Case LD, Kendal-Reed M, et al. (2003). "Nicotinic cholinergic receptor expression in the human nasal mucosa". Ann. Otol. Rhinol. Laryngol. 112 (1): 77–84. PMID 12537063.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ebihara M, Ohba H, Ohno SI, Yoshikawa T (2003). "Genomic organization and promoter analysis of the human nicotinic acetylcholine receptor alpha6 subunit (CHNRA6) gene: Alu and other elements direct transcriptional repression". Gene. 298 (1): 101–8. doi:10.1016/S0378-1119(02)00925-3. PMID 12406580.
- Graham A, Court JA, Martin-Ruiz CM, et al. (2002). "Immunohistochemical localisation of nicotinic acetylcholine receptor subunits in human cerebellum". Neuroscience. 113 (3): 493–507. doi:10.1016/S0306-4522(02)00223-3. PMID 12150770.
- Le Novère N, Zoli M, Changeux JP (1997). "Neuronal nicotinic receptor alpha 6 subunit mRNA is selectively concentrated in catecholaminergic nuclei of the rat brain". Eur. J. Neurosci. 8 (11): 2428–39. doi:10.1111/j.1460-9568.1996.tb01206.x. PMID 8950106.
- Elliott KJ, Ellis SB, Berckhan KJ, et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–28. doi:10.1007/BF02736842. PMID 8906617.
External links
- CHRNA6 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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