CPA superfamily
The CPA Superfamily is a group of transport proteins named after one of its constituent members, the monovalent cation:proton antiporter-2 (CPA2; TC# 2.A.37). According to a phylogenetic tree produced using proteins in TCDB and Clustal X, published by Chen et. al. (2010) it appears as though CPA1 used to also be a member of the CPA superfamily, until enough evidence was gathered to delegated it to the VIC superfamily.[1][2][3] As of April 2016, the CPA superfamily consists of four members:
- 2.A.37 - The Monovalent Cation:Proton Antiporter-2 (CPA2) Family
- 2.A.70 - The Malonate:Na+ Symporter (MSS) Family
- 2.A.98 - The Putative Sulfate Exporter (PSE) Family
- 3.B.1 - The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family
Structural variation exists between families. For example, members of the CPA2 family are between 300 and 900 amino acyl residues (aas) in length and exhibit 10 to 14 transmembrane segments (TMSs), while members of the MSS family are shorter than 300 aas and exhibit 4 to 7 TMSs.
See also
Further reading
- Chang, Abraham B.; Lin, Ron; Keith Studley, W.; Tran, Can V.; Saier, Milton H. (2004-06-01). "Phylogeny as a guide to structure and function of membrane transport proteins". Molecular Membrane Biology 21 (3): 171–181.doi:10.1080/09687680410001720830. ISSN 0968-7688.PMID 15204625
References
- ↑ Chen, Jonathan S.; Reddy, Vamsee; Chen, Joshua H.; Shlykov, Maksim A.; Zheng, Wei Hao; Cho, Jaehoon; Yen, Ming Ren; Saier, Milton H.; Jr. "Phylogenetic Characterization of Transport Protein Superfamilies: Superiority of SuperfamilyTree Programs over Those Based on Multiple Alignments". Journal of Molecular Microbiology and Biotechnology. 21 (3-4): 83–96. doi:10.1159/000334611. PMC 3290041
. PMID 22286036. - ↑ Koishi, Ryuta; Xu, Haoxing; Ren, Dejian; Navarro, Betsy; Spiller, Benjamin W.; Shi, Qing; Clapham, David E. (2004-03-05). "A superfamily of voltage-gated sodium channels in bacteria". The Journal of Biological Chemistry. 279 (10): 9532–9538. doi:10.1074/jbc.M313100200. ISSN 0021-9258. PMID 14665618.
- ↑ "1.A.1 The Voltage-gated Ion Channel (VIC) Superfamily". TCDB. Retrieved 2016-04-05.
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