CSN2

Identifiers

CSN2, CASB, casein beta

External IDs

MGI: 88541 HomoloGene: 1426 GeneCards: CSN2

Gene ontology
Molecular function	• calcium ion binding • enzyme inhibitor activity • transporter activity
Cellular component	• extracellular space • extracellular region
Biological process	• negative regulation of lactation • lactation • calcium ion transport • transport • negative regulation of catalytic activity
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


1447


12991

Ensembl


n/a


ENSMUSG00000063157

UniProt


P05814


P10598

RefSeq (mRNA)


NM_001302770 NM_001891

NM_001286020 NM_001286021 NM_001286022 NM_001286023 NM_001286024
NM_009972

RefSeq (protein)


NP_001289699.1 NP_001882.1


NP_001272949.1 NP_001272950.1 NP_001272952.1 NP_034102.1

Location (UCSC)

Chr 4: 69.96 – 69.96 Mb

Chr 5: 87.69 – 87.7 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Beta-casein is a protein that in humans is encoded by the CSN2 gene.^[3]^[4] It is in the class of phosphoproteins and generally occurs in mammalian milk.

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Menon RS, Chang YF, Jeffers KF, Jones C, Ham RG (Jun 1992). "Regional localization of human beta-casein gene (CSN2) to 4pter-q21". Genomics. 13 (1): 225–6. doi:10.1016/0888-7543(92)90227-J. PMID 1577486.
↑ "Entrez Gene: CSN2 casein beta".

Letwin K, Mizzen L, Motro B, et al. (1992). "A mammalian dual specificity protein kinase, Nek1, is related to the NIMA cell cycle regulator and highly expressed in meiotic germ cells.". EMBO J. 11 (10): 3521–31. PMC 556810. PMID 1382974.
Lönnerdal B, Bergström S, Andersson Y, et al. (1990). "Cloning and sequencing of a cDNA encoding human milk beta-casein.". FEBS Lett. 269 (1): 153–6. doi:10.1016/0014-5793(90)81142-B. PMID 2387396.
Menon RS, Ham RG (1989). "Human beta-casein: partial cDNA sequence and apparent polymorphism.". Nucleic Acids Res. 17 (7): 2869. doi:10.1093/nar/17.7.2869. PMC 317677. PMID 2717418.
Greenberg R, Groves ML, Dower HJ (1984). "Human beta-casein. Amino acid sequence and identification of phosphorylation sites.". J. Biol. Chem. 259 (8): 5132–8. PMID 6715339.
Chen CS, Bejcek BE, Kersey JH (1995). "A mapping study of 13 genes on human chromosome bands 4q11→q25.". Cytogenet. Cell Genet. 69 (3–4): 260–5. doi:10.1159/000133976. PMID 7698025.
Hansson L, Edlund A, Johansson T, et al. (1994). "Structure of the human beta-casein encoding gene". Gene. 139 (2): 193–9. doi:10.1016/0378-1119(94)90754-4. PMID 8112603.
McConkey EH, Menon R, Williams G, et al. (1996). "Assignment of the gene for beta-casein (CSN2) to 4q13 → q21 in humans and 3p13 → p12 in chimpanzees". Cytogenet. Cell Genet. 72 (1): 60–2. doi:10.1159/000134163. PMID 8565637.
Wilmouth RC, Clifton IJ, Robinson CV, et al. (1997). "Structure of a specific acyl-enzyme complex formed between beta-casomorphin-7 and porcine pancreatic elastase". Nat. Struct. Biol. 4 (6): 456–62. doi:10.1038/nsb0697-456. PMID 9187653.
Winklehner-Jennewein P, Geymayer S, Lechner J, et al. (1998). "A distal enhancer region in the human beta-casein gene mediates the response to prolactin and glucocorticoid hormones". Gene. 217 (1–2): 127–39. doi:10.1016/S0378-1119(98)00380-1. PMID 9795185.
Gray CW, Ward RV, Karran E, et al. (2000). "Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response". Eur. J. Biochem. 267 (18): 5699–710. doi:10.1046/j.1432-1327.2000.01589.x. PMID 10971580.
Sood SM, Slatter CW (2003). "Suspension of the calcium-sensitive human beta-caseins by human kappa-casein". J. Dairy Sci. 85 (6): 1353–6. doi:10.3168/jds.S0022-0302(02)74200-8. PMID 12146463.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ohashi A, Murata E, Yamamoto K, et al. (2003). "New functions of lactoferrin and beta-casein in mammalian milk as cysteine protease inhibitors". Biochem. Biophys. Res. Commun. 306 (1): 98–103. doi:10.1016/S0006-291X(03)00917-3. PMID 12788072.
Reimer T, Weiwad M, Schierhorn A, et al. (2003). "Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14". J. Mol. Biol. 330 (5): 955–66. doi:10.1016/S0022-2836(03)00713-7. PMID 12860119.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Miller SL, DeMaria JE, Freier DO, et al. (2005). "Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor". Mol. Endocrinol. 19 (4): 939–49. doi:10.1210/me.2004-0443. PMID 15618286.
Sood SM, Lekic T, Jhawar H, et al. (2007). "Reconstituted micelle formation using reduced, carboxymethylated bovine kappa-casein and human beta-casein". Protein J. 25 (5): 352–60. doi:10.1007/s10930-006-9022-7. PMID 16947075.
Buser AC, Gass-Handel EK, Wyszomierski SL, et al. (2007). "Progesterone receptor repression of prolactin/signal transducer and activator of transcription 5-mediated transcription of the beta-casein gene in mammary epithelial cells". Mol. Endocrinol. 21 (1): 106–25. doi:10.1210/me.2006-0297. PMID 16973758.

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CSN2

References

Further reading