Cbl TKB domain
| CBL proto-oncogene N-terminal domain 1 (four-helix bundle) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of the n-terminal domain of cbl in complex with its binding site in zap-70 | |||||||||
| Identifiers | |||||||||
| Symbol | Cbl_N | ||||||||
| Pfam | PF02262 | ||||||||
| InterPro | IPR003153 | ||||||||
| SCOP | 1b47 | ||||||||
| SUPERFAMILY | 1b47 | ||||||||
| |||||||||
| CBL proto-oncogene N-terminus, EF hand-like domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
structure of the n-terminal domain of cbl in complex with its binding site in zap-70 | |||||||||
| Identifiers | |||||||||
| Symbol | Cbl_N2 | ||||||||
| Pfam | PF02761 | ||||||||
| InterPro | IPR014741 | ||||||||
| SCOP | 1b47 | ||||||||
| SUPERFAMILY | 1b47 | ||||||||
| |||||||||
| CBL proto-oncogene N-terminus, SH2-like domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
|
structure of the n-terminal domain of cbl in complex with its binding site in zap-70 | |||||||||
| Identifiers | |||||||||
| Symbol | Cbl_N3 | ||||||||
| Pfam | PF02762 | ||||||||
| InterPro | IPR014742 | ||||||||
| SCOP | 1b47 | ||||||||
| SUPERFAMILY | 1b47 | ||||||||
| CDD | cd09920 | ||||||||
| |||||||||
In molecular biology, the Cbl TKB domain (tyrosine kinase binding domain), also known as the phosphotyrosine binding (PTB) domain is a conserved region found at the N-terminus of Cbl adaptor proteins. This N-terminal region is composed of three evolutionarily conserved domains: an N-terminal four-helix bundle domain, an EF hand-like domain and a SH2-like domain, which together are known to bind to phosphorylated tyrosine residues.
References
This article incorporates text from the public domain Pfam and InterPro IPR014742
This article incorporates text from the public domain Pfam and InterPro IPR014741
This article incorporates text from the public domain Pfam and InterPro IPR003153
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