CopA-like RNA

CopA-like RNA
Predicted secondary structure and sequence conservation of CopA
Identifiers
Symbol CopA
Rfam RF00042
Other data
RNA type Gene; antisense
Domain(s) Bacteria
SO 0000644

CopA-like RNA is a family of non-coding RNAs found on the R1 plasmid.

In several groups of bacterial plasmids, antisense RNAs regulate copy number through inhibition of replication initiator protein synthesis. These RNAs are characterised by a long hairpin structure interrupted by several unpaired nucleotides or bulged loops. In plasmid R1, the inhibitory complex between the antisense RNA (CopA) and its target mRNA (CopT) is characterised by a four-way junction structure and a side-by-side helical alignment.[1][2][3]

References

  1. Nordgren, S; Slagter-Jager JG; Wagner GH (2001). "Real time kinetic studies of the interaction between folded antisense and target RNAs using surface plasmon resonance". J Mol Biol. 310 (5): 11251134. doi:10.1006/jmbi.2001.4802. PMID 11502000.
  2. Gerhart E, Wagner H, Nordström K (1986). "Structural analysis of an RNA molecule involved in replication control of plasmid R1.". Nucleic Acids Res. 14 (6): 2523–38. doi:10.1093/nar/14.6.2523. PMC 339680Freely accessible. PMID 2421250.
  3. Jelloul N, Bouzouita H, Belkahia A (1979). "[Significance of impedance tests in childhood deafness].". Tunis Med. 57 (4-5): 236–40. PMID 555093.

External links


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