Cycloleucine
Names | |
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IUPAC name
1-Amino-1-cyclopentanecarboxylic acid | |
Other names
1-Aminocyclopentanecarboxylic acid | |
Identifiers | |
52-52-8 | |
3D model (Jmol) | Interactive image Interactive image |
ChEBI | CHEBI:40547 |
ChEMBL | ChEMBL295830 |
ChemSpider | 2798 |
DrugBank | DB04620 |
ECHA InfoCard | 100.000.132 |
KEGG | C03969 |
PubChem | 2901 |
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Properties | |
C6H11NO2 | |
Molar mass | 129.16 g/mol |
Appearance | white of beige crystalline flakes or powder |
Density | 1.207 g/mL |
Melting point | 320 °C (608 °F; 593 K) |
Boiling point | 256.1 °C (493.0 °F; 529.2 K) |
50 mg/mL | |
Hazards | |
Main hazards | Irritant |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Cycloleucine is a non-proteinogenic amino acid. It could be classified as a cyclic derivate of norleucine, having two hydrogen atoms less. Leading structure is a cyclopentane-ring. The α-carbon atom is not a stereocenter.
Cycloleucine is a non-metabolisable amino acid and is a specific and reversible inhibitor of nucleic acid methylation, and as such is widely used in biochemical experiments.[2]
References
- ↑ Cycloleucine at Sigma-Aldrich
- ↑ M Caboche and JP Bachellerie (1977). "RNA methylation and control of eukaryotic RNA biosynthesis. Effects of cycloleucine, a specific inhibitor of methylation, on ribosomal RNA maturation". European Journal of Biochemistry. 74 (1): 19–29. doi:10.1111/j.1432-1033.1977.tb11362.x. PMID 856572.
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