DDX11

DDX11
Identifiers
Aliases DDX11, CHL1, CHLR1, KRG2, WABS, DEAD/H-box helicase 11
External IDs MGI: 2443590 HomoloGene: 68973 GeneCards: DDX11
Orthologs
Species Human Mouse
Entrez

1663

320209

Ensembl

ENSG00000013573

ENSMUSG00000035842

UniProt

Q96FC9

Q6AXC6

RefSeq (mRNA)

NM_001003919

RefSeq (protein)

NP_001244073.1
NP_001244074.1
NP_004390.3
NP_689651.1

NP_001003919.1

Location (UCSC) Chr 12: 31.07 – 31.1 Mb Chr 17: 66.12 – 66.15 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Probable ATP-dependent RNA helicase DDX11 is an enzyme that in humans is encoded by the DDX11 gene.[3]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an enzyme that possesses both ATPase and DNA helicase activities. This gene is a homolog of the yeast CHL1 gene, and may function to maintain chromosome transmission fidelity and genome stability. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[3]

References

Further reading


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