DTYMK

DTYMK

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1E9F, 1E9E, 1NMY, 1E2G, 1E9D, 1E98, 1E2E, 1NN0, 1E2Q, 1E9C, 1E2F, 1NN5, 1E99, 2XX3, 1NMZ, 1E9A, 1E2D, 1E9B, 1NMX, 1NN1, 1NN3

Identifiers

DTYMK, CDC8, PP3731, TMPK, TYMK, deoxythymidylate kinase

External IDs

MGI: 108396 HomoloGene: 6285 GeneCards: DTYMK

Gene ontology
Molecular function	• transferase activity • nucleotide binding • uridylate kinase activity • kinase activity • thymidylate kinase activity • nucleoside phosphate kinase activity • ATP binding
Cellular component	• mitochondrial intermembrane space • mitochondrial matrix • mitochondrion • cytosol • nucleus
Biological process	• nucleobase-containing small molecule interconversion • nucleotide biosynthetic process • response to cadmium ion • phosphorylation • cellular response to growth factor stimulus • dTTP biosynthetic process • response to estrogen • dTDP biosynthetic process • cell cycle • dUDP biosynthetic process • myoblast differentiation • cell proliferation • nucleoside monophosphate phosphorylation • nucleotide phosphorylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse


1841


21915


ENSG00000168393


ENSMUSG00000026281


P23919


P97930

RefSeq (mRNA)

NM_001165031 NM_012145 NM_001320902 NM_001320903 NM_001320904
NM_001320905


NM_001105667 NM_023136

RefSeq (protein)


NP_001158503.1 NP_036277.2 NP_001307832.1


NP_001099137.1

Location (UCSC)

Chr 2: 241.68 – 241.69 Mb

Chr 1: 93.79 – 93.8 Mb

PubMed search

^[1]

^[2]

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Thymidylate kinase also known as deoxythymidylate kinase or dTMP kinase is an enzyme that in humans is encoded by the DTYMK gene.^[3]^[4]^[5] and belongs to thymidylate kinase family of proteins.

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Su JY, Sclafani RA (May 1991). "Molecular cloning and expression of the human deoxythymidylate kinase gene in yeast". Nucleic Acids Res. 19 (4): 823–7. doi:10.1093/nar/19.4.823. PMC 333717. PMID 2017365.
↑ Huang SH, Tang A, Drisco B, Zhang SQ, Seeger R, Li C, Jong A (Aug 1994). "Human dTMP kinase: gene expression and enzymatic activity coinciding with cell cycle progression and cell growth". DNA Cell Biol. 13 (5): 461–71. doi:10.1089/dna.1994.13.461. PMID 8024690.
↑ "Entrez Gene: DTYMK deoxythymidylate kinase (thymidylate kinase)".

Further reading

Van Rompay AR, Johansson M, Karlsson A (2000). "Phosphorylation of nucleosides and nucleoside analogs by mammalian nucleoside monophosphate kinases.". Pharmacol. Ther. 87 (2-3): 189–98. doi:10.1016/S0163-7258(00)00048-6. PMID 11008000.
Tamiya N, Yusa T, Yamaguchi Y, et al. (1989). "Co-purification of thymidylate kinase and cytosolic thymidine kinase from human term placenta by affinity chromatography.". Biochim. Biophys. Acta. 995 (1): 28–35. doi:10.1016/0167-4838(89)90229-X. PMID 2538159.
Cummins RR, Balinsky D (1980). "Activities of some enzymes of pyrimidine and DNA synthesis in a rat transplantable hepatoma and human primary hepatomas, in cell lines derived from these tissues, and in human fetal liver.". Cancer Res. 40 (4): 1235–9. PMID 6244089.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene. 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene. 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ostermann N, Segura-Peña D, Meier C, et al. (2003). "Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds.". Biochemistry. 42 (9): 2568–77. doi:10.1021/bi027302t. PMID 12614151.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

PDB gallery

1e2d: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION

1e2e: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE,A MAGNESIUM-ION AND ALF3

1e2f: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE, ADENOSINE DIPHOSPHATE AND A MAGNESIUM-ION

1e2g: HUMAN THYMIDYLATE KINASE COMPLEXED WITH ADP, TDP AND A MAGNESIUM-ION

1e2q: HUMAN THYMIDYLATE KINASE COMPLEXED WITH TP5A AND A MAGNESIUM-ION

1e98: WILD TYPE HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP

1e99: HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND ADP

1e9a: HUMAN THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR AZTP5A

1e9b: HUMAN THYMIDYLATE KINASE COMPLEXED WITH AZTMP AND APPNP

1e9c: MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND APPNP

1e9d: MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH AZTMP AND ADP

1e9e: MUTANT HUMAN THYMIDYLATE KINASE (F105Y) COMPLEXED WITH DTMP AND ADP

1e9f: MUTANT HUMAN THYMIDYLATE KINASE COMPLEXED WITH TMP AND ADP

1nmx: Crystal structure of human thymidylate kinase with FLTMP and ADP

1nmy: Crystal structure of human thymidylate kinase with FLTMP and AppNHp

1nmz: Crystal structure of human thymidylate kinase with NH2TMP and AppNHp

1nn0: Crystal structure of human thymidylate kinase with ddTMP and ADP

1nn1: Crystal structure of human thymidylate kinase with ddTMP and AppNHp

1nn3: Crystal structure of human thymidylate kinase with d4TMP + ADP

1nn5: Crystal structure of human thymidylate kinase with d4TMP + AppNHp

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