Eduardo Arzt

Eduardo Arzt
Born February 22 - 1953
Buenos Aires, Argentina
Nationality Argentina
Fields Molecular Biology
Institutions CONICET, Max Planck Society, UBA
Notable awards Guggenheim Fellowship, Houssay award, Bunge y Born award, Konex award

Eduardo Arzt (born in Buenos Aires, February 22, 1953) is an Argentine Molecular Biologist, Master in Experimental Biology, Doctor from the Faculty of Pharmacy and Biochemistry (University of Buenos Aires). Currently, a Senior Researcher at CONICET, Professor of the Faculty of Natural Sciences, University of Buenos Aires, External Scientific Member of the Max Planck Society (Germany) and Director of the Biomedicine Research Institute of Buenos Aires[1] - CONICET - Partner Institute of the Max Planck Society.

Contribution and recognition

His scientific contributions stand him out as an internationally recognized personality in the field of Molecular Neuroendocrinology. His laboratory contributed to the discovery of new genes and pathways involved in the physiological adaptation to homeostasis in response to stress,[2][3] hypoxia (lack of cellular oxygen),[4][5] physiopathological processes (pituitary tumors),[6][7][8][9][10][11][12][13] discovering new targets for pharmacological treatments.[14][15][16]

His recognition is based not only on his findings, which are an example of research in biomedicine, transferring results from basic molecular biology to pharmacological applications,[17][18][19] but also on his vast institutional achievements for Argentinean and Latin-American science,[20] including an active and important role in the development and realization of the project of the Polo Científico Tecnológico[21] and the creation of the Biomedicine Research Institute of Buenos Aires[22][23] - CONICET - Partner Institute of the Max Planck Society. He has received, for its ongoing work, both prestigious Argentine (Bunge and Born, Houssay Award) and International (Guggenheim Fellowship, External Scientific Member of the Max Planck Society, Order of Merit of the Federal Republic of Germany)[23][24] awards and distinctions.

Bibliographic review / career

In 1970 he graduated from the Colegio Nacional Buenos Aires, Argentina. In 1971 he joined the Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina, graduating in 1978. In 1981 he began a Masters in Experimental Biology at the Universidad Autonoma Metropolitana, Mexico, finishing his Master Thesis in Transportation models in biological membranes in 1984. From 1985 to 1988, Faculty of Pharmacy and Biochemistry (UBA), he developed his Ph.D. thesis in cellular mechanisms involved in immune-neuroendocrine pathways, in the Institute for Medical Research A. Lanari, Faculty of Medicine (UBA). In 1989 he joined the Scientific Researcher Career of CONICET, Argentina. In 1995 he obtained the position of Professor in Molecular and Cellular Biology, Faculty of Natural Sciences (UBA). In 1997 he participated as co-Founder and Director of the Laboratorio de Fisiología y Biología Molecular (LFBM-FCEN-UBA). In 2005 he was appointed External Scientific Member of the Max Planck Society.[25][26] In 2007 he participated in the agreement for the establishment of the Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society (IBioBA),[1] whose construction was completed in 2012 at the Polo Científico y Tecnológico.[27]

Awards and distinctions

References

  1. 1 2 Biomedicine Research Institute of Buenos Aires - CONICET - MPSP - official website.
  2. ↑ Refojo D, Echenique C, Müller MB, et al. (April 2005). "Corticotropin-releasing hormone activates ERK1/2 MAPK in specific brain areas". Proceedings of the National Academy of Sciences of the United States of America. 102 (17): 6183–8. doi:10.1073/pnas.0502070102. PMC 1087957Freely accessible. PMID 15833812.
  3. ↑ Arzt E, Holsboer F (October 2006). "CRF signaling: molecular specificity for drug targeting in the CNS". Trends in Pharmacological Sciences. 27 (10): 531–8. doi:10.1016/j.tips.2006.08.007. PMID 16935354.
  4. ↑ Druker J, Liberman AC, Antunica-Noguerol M, et al. (June 2013). "RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity". Molecular and Cellular Biology. 33 (11): 2116–27. doi:10.1128/MCB.01470-12. PMC 3648064Freely accessible. PMID 23508108.
  5. ↑ Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. (October 2007). "RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia". Cell. 131 (2): 309–23. doi:10.1016/j.cell.2007.07.044. PMID 17956732.
  6. ↑ Arzt E, Stelzer G, Renner U, Lange M, Müller OA, Stalla GK (November 1992). "Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures". The Journal of Clinical Investigation. 90 (5): 1944–51. doi:10.1172/JCI116072. PMC 443256Freely accessible. PMID 1331177.
  7. ↑ Arzt E, Buric R, Stelzer G, et al. (January 1993). "Interleukin involvement in anterior pituitary cell growth regulation: effects of IL-2 and IL-6". Endocrinology. 132 (1): 459–67. doi:10.1210/endo.132.1.8419142. PMID 8419142.
  8. ↑ Arzt E, Pereda MP, Castro CP, Pagotto U, Renner U, Stalla GK (January 1999). "Pathophysiological role of the cytokine network in the anterior pituitary gland". Frontiers in Neuroendocrinology. 20 (1): 71–95. doi:10.1006/frne.1998.0176. PMID 9882537.
  9. ↑ Arzt E (December 2001). "gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways". The Journal of Clinical Investigation. 108 (12): 1729–33. doi:10.1172/JCI14660. PMC 209477Freely accessible. PMID 11748253.
  10. ↑ Giacomini D, Páez-Pereda M, Stalla J, Stalla GK, Arzt E (July 2009). "Molecular interaction of BMP-4, TGF-beta, and estrogens in lactotrophs: impact on the PRL promoter". Molecular Endocrinology. 23 (7): 1102–14. doi:10.1210/me.2008-0425. PMID 19342445.
  11. ↑ Perez-Castro C, Renner U, Haedo MR, Stalla GK, Arzt E (January 2012). "Cellular and molecular specificity of pituitary gland physiology". Physiological Reviews. 92 (1): 1–38. doi:10.1152/physrev.00003.2011. PMID 22298650.
  12. ↑ Paez-Pereda M, Giacomini D, Refojo D, et al. (February 2003). "Involvement of bone morphogenetic protein 4 (BMP-4) in pituitary prolactinoma pathogenesis through a Smad/estrogen receptor crosstalk". Proceedings of the National Academy of Sciences of the United States of America. 100 (3): 1034–9. doi:10.1073/pnas.0237312100. PMC 298721Freely accessible. PMID 12552124.
  13. ↑ Arzt E, Chesnokova V, Stalla GK, Melmed S (March 2009). "Pituitary adenoma growth: a model for cellular senescence and cytokine action". Cell Cycle. 8 (5): 677–8. doi:10.4161/cc.8.5.8065. PMC 2710531Freely accessible. PMID 19223763.
  14. ↑ Giacomini D, Páez-Pereda M, Theodoropoulou M, et al. (January 2006). "Bone morphogenetic protein-4 inhibits corticotroph tumor cells: involvement in the retinoic acid inhibitory action". Endocrinology. 147 (1): 247–56. doi:10.1210/en.2005-0958. PMID 16195406.
  15. ↑ Castillo V, Giacomini D, Páez-Pereda M, et al. (September 2006). "Retinoic acid as a novel medical therapy for Cushing's disease in dogs". Endocrinology. 147 (9): 4438–44. doi:10.1210/en.2006-0414. PMID 16740975.
  16. ↑ Páez-Pereda, Marcelo; Arzt, Eduardo; Stalla, Günter K (2002). "Cushing's syndrome: Drug targets and therapeutic options". Expert Opinion on Therapeutic Patents. 12 (10): 1537–46. doi:10.1517/13543776.12.10.1537.
  17. ↑ Descubren un gen maestro para entender la maquinaria celular, by Nora Bär. Diario La Nación (Argentina), 10/19/2007. (spanish)
  18. ↑ Científicos argentinos hallan un gen maestro para luchar contra el cáncer, by Valeria Román. Diario Clarín (Argentina), 10/19/2007. (spanish)
  19. ↑ Prueban con éxito una terapia para la enfermedad de Cushing, Diario La Nación (Argentina), 10/13/2006.
  20. ↑ Arzt E (November 2012). "Collaboration: Biomedical network in South America". Nature. 491 (7424): 333. doi:10.1038/491333d. PMID 23151571.
  21. ↑ Ciencia entre Palermo Soho y Palermo Hollywood, by Paula Rodriguez, Deutsche Welle site, 12/21/2009.
  22. ↑ Primer Mundo, en Palermo: el imponente Instituto Max Planck, by Nora Bär, Diario La Nación(Argentina), 11/26/2012. (spanish)
  23. 1 2 3 Centro Alemán de Información para Latinoamérica y España - official website.
  24. 1 2 Orden del Mérito, Página 12 (Argentina), 07/20/2011. (spanish)
  25. 1 2 Max Planck Institute Psychiatry Munich.
  26. 1 2 Importante distinción a dos científicos argentinos, by Nora Bär, Diario La Nación (Argentina), 08/09/2005. (spanish)
  27. ↑ Polo Científico Tecnológico - official website. (spanish)
  28. ↑ John Simon Guggenheim Memorial Foundation.
  29. ↑ Fundación Bunge y Born - web site. Experimental medicine award.
  30. ↑ Premio Bunge y Born a dos investigadores del CONICET, by Nora Bär, Diario La Nación (Argentina), 05/23/2008. (spanish)
  31. ↑ Premio Bunge y Born para un prestigioso investigador, by Valeria Román, Diario Clarín (Argentina), 08/13/2008. (spanish)
  32. ↑ Fundación Konex, official website. Konex award 2013: Molecular Biology and Biochemistry.
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