Ets variant 3

ETV3

Identifiers

ETV3, METS, PE-1, PE1, bA110J1.4, ETS variant 3

External IDs

MGI: 1350926 HomoloGene: 21085 GeneCards: ETV3

Gene ontology
Molecular function	• transcription factor activity, sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • DEAD/H-box RNA helicase binding • molecular function • DNA binding • sequence-specific DNA binding • RNA polymerase II regulatory region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
Cellular component	• RNA polymerase II transcription repressor complex • nuclear chromatin • transcriptional repressor complex • nucleus
Biological process	• regulation of transcription from RNA polymerase II promoter • cell differentiation • regulation of transcription, DNA-templated • negative regulation of transcription from RNA polymerase II promoter • cellular response to granulocyte macrophage colony-stimulating factor stimulus • biological process • transcription, DNA-templated • negative regulation of cell proliferation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2117


27049

Ensembl


ENSG00000117036


ENSMUSG00000003382

UniProt


P41162


Q8R4Z4

RefSeq (mRNA)


NM_001145312 NM_005240


NM_001083318 NM_001286844 NM_012051

RefSeq (protein)


NP_001138784.1 NP_005231.1


NP_001076787.1 NP_001273773.1 NP_036181.3

Location (UCSC)

Chr 1: 157.12 – 157.14 Mb

Chr 3: 87.53 – 87.54 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Ets variant 3 is a protein that in humans is encoded by the ETV3 gene. ^[3]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ "Entrez Gene: Ets variant 3". Retrieved 2014-09-11.

Klemsz, M; Hromas, R; Raskind, W; Bruno, E; Hoffman, R (1994). "PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23". Genomics. 20 (2): 291–4. doi:10.1006/geno.1994.1169. PMID 8020980.
Hester, K. D.; Verhelle, D; Escoubet-Lozach, L; Luna, R; Rose, D. W.; Glass, C. K. (2007). "Differential repression of c-myc and cdc2 gene expression by ERF and PE-1/METS". Cell cycle (Georgetown, Tex.). 6 (13): 1594–604. doi:10.4161/cc.6.13.4336. PMID 17525531.
Anney, R. J. L.; Lasky-Su, J.; ó'Dúshláine, C.; Kenny, E.; Neale, B. M.; Mulligan, A.; Franke, B.; Zhou, K.; Chen, W.; Christiansen, H.; Arias-Vásquez, A.; Banaschewski, T.; Buitelaar, J.; Ebstein, R.; Miranda, A.; Mulas, F.; Oades, R. D.; Roeyers, H.; Rothenberger, A.; Sergeant, J.; Sonuga-Barke, E.; Steinhausen, H.; Asherson, P.; Faraone, S. V.; Gill, M. (2008). "Conduct disorder and ADHD: Evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study". American Journal of Medical Genetics Part B. 147B (8): 1369–1378. doi:10.1002/ajmg.b.30871. PMID 18951430.
Sawka-Verhelle, D; Escoubet-Lozach, L; Fong, A. L.; Hester, K. D.; Herzig, S; Lebrun, P; Glass, C. K. (2004). "PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation". Journal of Biological Chemistry. 279 (17): 17772–84. doi:10.1074/jbc.M311991200. PMID 14754893.
Klappacher, G. W.; Lunyak, V. V.; Sykes, D. B.; Sawka-Verhelle, D; Sage, J; Brard, G; Ngo, S. D.; Gangadharan, D; Jacks, T; Kamps, M. P.; Rose, D. W.; Rosenfeld, M. G.; Glass, C. K. (2002). "An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation". Cell. 109 (2): 169–80. doi:10.1016/S0092-8674(02)00714-6. PMID 12007404.
Mesquita, B; Lopes, P; Rodrigues, A; Pereira, D; Afonso, M; Leal, C; Henrique, R; Lind, G. E.; Jerónimo, C; Lothe, R. A.; Teixeira, M. R. (2013). "Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors ETV3 and ELF3 in breast cancer irrespective of molecular subtypes". Breast Cancer Research and Treatment. 138 (1): 37–45. doi:10.1007/s10549-013-2408-2. PMID 23329352.
El Kasmi, K. C.; Smith, A. M.; Williams, L.; Neale, G.; Panopoulos, A. D.; Watowich, S. S.; Häcker, H.; Foxwell, B. M.; Murray, P. J. (2007). "Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway". Journal of immunology (Baltimore, Md. : 1950). 179 (11): 7215–7219. doi:10.4049/jimmunol.179.11.7215. PMID 18025162.

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Ets variant 3

References

Further reading