FZD1

FZD1
Identifiers
Aliases	FZD1
External IDs	MGI: 1196625 HomoloGene: 20750 GeneCards: FZD1
Gene ontology Molecular function • PDZ domain binding • G-protein coupled receptor activity • frizzled binding • signal transducer activity • Wnt-protein binding • protein binding • Wnt-activated receptor activity • receptor binding • transmembrane signaling receptor activity Cellular component • integral component of membrane • Wnt signalosome • membrane • focal adhesion • plasma membrane • cell surface Biological process • G-protein coupled receptor signaling pathway • non-canonical Wnt signaling pathway • positive regulation of protein phosphorylation • autocrine signaling • epithelial cell differentiation • muscular septum morphogenesis • ventricular septum morphogenesis • cell-cell signaling • membranous septum morphogenesis • outflow tract morphogenesis • positive regulation of sequence-specific DNA binding transcription factor activity • Wnt signaling pathway • planar cell polarity pathway involved in neural tube closure • negative regulation of BMP signaling pathway • positive regulation of transcription, DNA-templated • multicellular organism development • cell surface receptor signaling pathway • canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation • canonical Wnt signaling pathway involved in osteoblast differentiation • hard palate development • neuron differentiation • canonical Wnt signaling pathway • synapse assembly • negative regulation of catenin import into nucleus • negative regulation of transcription, DNA-templated • negative regulation of canonical Wnt signaling pathway • response to drug • signal transduction • Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation • beta-catenin destruction complex disassembly • Wnt signaling pathway, planar cell polarity pathway Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8321	14362
Ensembl	ENSG00000157240	ENSMUSG00000044674
UniProt	Q9UP38	O70421
RefSeq (mRNA)	NM_003505	NM_021457
RefSeq (protein)	NP_003496.1	NP_067432.2
Location (UCSC)	Chr 7: 91.26 – 91.27 Mb	Chr 5: 4.75 – 4.76 Mb
PubMed search	[1]	[2]
Wikidata

Frizzled-1 is a protein that in humans is encoded by the FZD1 gene.^[3][4]

Function

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif. The FZD1 transcript is expressed in various tissues.^[4]

See also

• Frizzled

References

Further reading

External links

• "Frizzled Receptors: FZD₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.