GABA transaminase
A GABA transaminase is an enzyme that catalyzes chemical reactions. There are two types of this enzyme:
- 4-aminobutyrate transaminase, which catalyzes the chemical reaction:
- 4-aminobutanoate + 2-oxoglutarate
succinate semialdehyde + L-glutamate
- 4-aminobutanoate + 2-oxoglutarate
and
- 4-aminobutyrate—pyruvate transaminase, which catalyzes the chemical reaction:
- (1) 4-aminobutanoate + pyruvate
succinate semialdehyde + L-alanine
- (2) 4-aminobutanoate + glyoxylate
succinate semialdehyde + glycine
- (1) 4-aminobutanoate + pyruvate
GABA transaminase is targeted by multiple antiepileptic and analgesic drugs referred to as GABA transaminase inhibitors.
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