GCAT

GCAT
Identifiers
Aliases GCAT, KBL, glycine C-acetyltransferase
External IDs MGI: 1349389 HomoloGene: 8475 GeneCards: GCAT
Orthologs
Species Human Mouse
Entrez

23464

26912

Ensembl

ENSG00000100116

ENSMUSG00000006378

UniProt

O75600

O88986

RefSeq (mRNA)

NM_001171690
NM_014291

NM_001161712
NM_013847

RefSeq (protein)

NP_001165161.1
NP_055106.1

NP_038875.3

Location (UCSC) Chr 22: 37.81 – 37.82 Mb Chr 15: 79.03 – 79.04 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene.[3]

Function

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.

References

Further reading

  • Jacquot C, Lanco X, Carbonnelle D, Sevestre O, Tomasoni C, Briad G, Juget M, Roussis V, Roussakis C (2002). "Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation arrest in a non-small cell bronchopulmonary cancer line". Anticancer Research. 22 (4): 2229–35. PMID 12174908. 
  • Tressel T, Thompson R, Zieske LR, Menendez MI, Davis L (Dec 1986). "Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production". The Journal of Biological Chemistry. 261 (35): 16428–37. PMID 3536927. 
  • Edgar AJ, Polak JM (Mar 2000). "Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs". European Journal of Biochemistry / FEBS. 267 (6): 1805–12. doi:10.1046/j.1432-1327.2000.01175.x. PMID 10712613. 
  • Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Iashikawa, K., Nakada, K., ... & Hayashi, J. I. (2015). "Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects". Scientific Reports. 5 (10434). doi:10.1038/srep10434. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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