George Spence
George Spence may refer to:
- George Spence (politician) (1880–1975), Canadian provincial and federal politician
- George Spence (MP), Member of Parliament for Ripon, 1829–1832
- George Spence (footballer, born 1877), Scottish football player for Preston, Southampton and Hull
- George Spence (footballer, born 1904), English football player for Nelson
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