Ghrelin O-acyltransferase

MBOAT4
Identifiers
Aliases MBOAT4, GOAT, OACT4, FKSG89, membrane bound O-acyltransferase domain containing 4
External IDs MGI: 2685017 HomoloGene: 19272 GeneCards: MBOAT4
Orthologs
Species Human Mouse
Entrez

619373

234155

Ensembl

ENSG00000177669

ENSMUSG00000071113

UniProt

Q96T53

P0C7A3

RefSeq (mRNA)

NM_001100916

NM_001126314

RefSeq (protein)

NP_001094386.1

NP_001119786.1

Location (UCSC) Chr 8: 30.13 – 30.14 Mb Chr 8: 34.12 – 34.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Ghrelin O-acyltransferase also known as membrane bound O-acyltransferase domain containing 4 is an enzyme that in humans is encoded by the MBOAT4 gene.[3] It is homologous to other membrane-bound O-acyltransferases.

References

  1. ↑ "Human PubMed Reference:".
  2. ↑ "Mouse PubMed Reference:".
  3. ↑ "Entrez Gene: Membrane bound O-acyltransferase domain containing 4".

Further Reading

  • Gómez, R; Lago, F; Gómez-Reino, J. J.; Dieguez, C; Gualillo, O (2009). "Expression and modulation of ghrelin O-acyltransferase in cultured chondrocytes". Arthritis & Rheumatism. 60 (6): 1704–9. doi:10.1002/art.24522. PMID 19479831. 
  • Gutierrez, J. A.; Solenberg, P. J.; Perkins, D. R.; Willency, J. A.; Knierman, M. D.; Jin, Z; Witcher, D. R.; Luo, S; Onyia, J. E.; Hale, J. E. (2008). "Ghrelin octanoylation mediated by an orphan lipid transferase". Proceedings of the National Academy of Sciences. 105 (17): 6320–5. doi:10.1073/pnas.0800708105. PMC 2359796Freely accessible. PMID 18443287. 
  • Rodríguez, A; Gómez-Ambrosi, J; Catalán, V; Rotellar, F; Valentí, V; Silva, C; Mugueta, C; Pulido, M. R.; Vázquez, R; Salvador, J; Malagón, M. M.; Colina, I; Frühbeck, G (2012). "The ghrelin O-acyltransferase-ghrelin system reduces TNF-α-induced apoptosis and autophagy in human visceral adipocytes". Diabetologia. 55 (11): 3038–50. doi:10.1007/s00125-012-2671-5. PMID 22869322. 
  • Takahashi, T; Ida, T; Sato, T; Nakashima, Y; Nakamura, Y; Tsuji, A; Kojima, M (2009). "Production of n-octanoyl-modified ghrelin in cultured cells requires prohormone processing protease and ghrelin O-acyltransferase, as well as n-octanoic acid". Journal of Biochemistry. 146 (5): 675–82. doi:10.1093/jb/mvp112. PMID 19628676. 
  • Lim, C. T.; Kola, B; Grossman, A; Korbonits, M (2011). "The expression of ghrelin O-acyltransferase (GOAT) in human tissues". Endocrine journal. 58 (8): 707–10. doi:10.1507/endocrj.k11e-117. PMID 21646729. 
  • Liu, B; Garcia, E. A.; Korbonits, M (2011). "Genetic studies on the ghrelin, growth hormone secretagogue receptor (GHSR) and ghrelin O-acyl transferase (GOAT) genes". Peptides. 32 (11): 2191–207. doi:10.1016/j.peptides.2011.09.006. PMID 21930173. 
  • Heppner, K. M.; Tong, J; Kirchner, H; Nass, R; Tschöp, M. H. (2011). "The ghrelin O-acyltransferase-ghrelin system: A novel regulator of glucose metabolism". Current Opinion in Endocrinology, Diabetes and Obesity. 18 (1): 50–5. doi:10.1097/MED.0b013e328341e1d3. PMID 21150588. 
  • Müller, T. D.; Tschöp, M. H.; Jarick, I; Ehrlich, S; Scherag, S; Herpertz-Dahlmann, B; Zipfel, S; Herzog, W; De Zwaan, M; Burghardt, R; Fleischhaker, C; Klampfl, K; Wewetzer, C; Herpertz, S; Zeeck, A; Tagay, S; Burgmer, M; Pfluger, P. T.; Scherag, A; Hebebrand, J; Hinney, A (2011). "Genetic variation of the ghrelin activator gene ghrelin O-acyltransferase (GOAT) is associated with anorexia nervosa". Journal of Psychiatric Research. 45 (5): 706–11. doi:10.1016/j.jpsychires.2010.10.001. PMID 21035823. 
This article is issued from Wikipedia - version of the 5/20/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.