Glycoside hydrolase family 13

Alpha amylase, N-terminal ig-like domain

crystal structure of thermoactinomyces vulgaris r-47 alpha-amylase 1 (tvai) mutant d356n/e396q complexed with p2, a pullulan model oligosaccharide
Identifiers
Symbol Alpha-amylase_N
Pfam PF02903
InterPro IPR004185
SCOP 1sma
SUPERFAMILY 1sma
Alpha-amylase catalytic domain

cyclodextrin glucanotransferase (e.c.2.4.1.19) (cgtase)
Identifiers
Symbol Alpha-amylase
Pfam PF00128
Pfam clan CL0058
InterPro IPR006047
SCOP 1ppi
SUPERFAMILY 1ppi
CAZy GH13

In molecular biology, glycoside hydrolase family 13 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[5]

Enzymes containing this domain belong to family 13 (CAZY GH_13) of the glycosyl hydrolases. The maltogenic alpha-amylase is an enzyme which catalyses hydrolysis of (1-4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains in the conversion of starch to maltose. Other enzymes in this family include neopullulanase, which hydrolyses pullulan to panose, and cyclomaltodextrinase, which hydrolyses cyclodextrins.

References

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