Glycoside hydrolase family 34
| Neuraminidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Crystallographic structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | Neur | ||||||||
| Pfam | PF00064 | ||||||||
| Pfam clan | CL0434 | ||||||||
| InterPro | IPR001860 | ||||||||
| SCOP | 2bat | ||||||||
| SUPERFAMILY | 2bat | ||||||||
| CAZy | GH34 | ||||||||
| CDD | cd00260 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 34 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[2][3][4] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6]
Glycoside hydrolase family 34 CAZY GH_34 comprises enzymes with only one known activity; sialidase or neuraminidase EC 3.2.1.18. Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. In Influenza virus, neuraminidases prevent self-aggregation by removing the carbohydrate from the viral envelope thus facilitating the mobility of the virus to and from the site of infection. Antiviral agents that inhibit influenza viral neuraminidase activity are of major importance in the control of influenza.[7]
References
- ↑ PDB: 1nna; Bossart-Whitaker P, Carson M, Babu YS, Smith CD, Laver WG, Air GM (August 1993). "Three-dimensional structure of influenza A N9 neuraminidase and its complex with the inhibitor 2-deoxy 2,3-dehydro-N-acetyl neuraminic acid". J. Mol. Biol. 232 (4): 1069–83. doi:10.1006/jmbi.1993.1461. PMID 8371267.
- ↑ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477
. PMID 7624375. - ↑ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
- ↑ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
- ↑ CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
- ↑ Couch RB (1999). "Measures for control of influenza". PharmacoEconomics. 16: 41–45. doi:10.2165/00019053-199916001-00006. PMID 10623375.