Glycoside hydrolase family 98
| Glycosyl hydrolase family 98 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glyco_hydro_98M | ||||||||
| Pfam | PF08306 | ||||||||
| InterPro | IPR013191 | ||||||||
| CAZy | GH98 | ||||||||
| |||||||||
| Glycosyl hydrolase family 98 C-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | Glyco_hydro_98C | ||||||||
| Pfam | PF08307 | ||||||||
| InterPro | IPR013190 | ||||||||
| |||||||||
In molecular biology, glycoside hydrolase family 98 is a family of glycoside hydrolases.
Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[5]
Members of glycoside hydrolase family 98 have endo-β-galactosidase activity. This family includes E-ABase from Clostridium perfringens which cleaves both blood group A and B glycotopes.[6]
The putative catalytic domain is found to the N-terminus of a second domain, which is not expected to form part of the catalytic activity.
References
- ↑ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477
. PMID 7624375. - ↑ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure. 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779.
- ↑ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
- ↑ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
- ↑ CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
- ↑ Anderson KM, Ashida H, Maskos K, Dell A, Li SC, Li YT (2005). "A clostridial endo-beta-galactosidase that cleaves both blood group A and B glycotopes: the first member of a new glycoside hydrolase family, GH98.". J Biol Chem. 280 (9): 7720–8. doi:10.1074/jbc.M414099200. PMID 15618227.
This article incorporates text from the public domain Pfam and InterPro IPR013190
This article incorporates text from the public domain Pfam and InterPro IPR013191