Growth hormone 1

GH1
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1AXI, 1HUW, 1A22, 1HGU, 3HHR, 1KF9, 1HWG, 1BP3, 1HWH
Identifiers
Aliases	GH1, GH, GH-N, GHN, IGHD1B, hGH-N, GHB5, Growth hormone 1
External IDs	HomoloGene: 128036 GeneCards: GH1
Gene ontology Molecular function • hormone activity • metal ion binding • protein binding • growth factor activity • growth hormone receptor binding • prolactin receptor binding Cellular component • extracellular space • extracellular region • intracellular Biological process • JAK-STAT cascade • JAK-STAT cascade involved in growth hormone signaling pathway • response to estradiol • positive regulation of MAP kinase activity • positive regulation of receptor internalization • positive regulation of tyrosine phosphorylation of Stat5 protein • positive regulation of tyrosine phosphorylation of Stat3 protein • bone maturation • growth hormone receptor signaling pathway • positive regulation of insulin-like growth factor receptor signaling pathway • positive regulation of multicellular organism growth • positive regulation of peptidyl-tyrosine phosphorylation • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of JAK-STAT cascade • glucose transport • positive regulation of activation of JAK2 kinase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2688	n/a
Ensembl	ENSG00000259384	n/a
UniProt	P01241	n/a
RefSeq (mRNA)	NM_000515 NM_022559 NM_022560 NM_022561 NM_022562	n/a
RefSeq (protein)	NP_000506.2 NP_072053.1 NP_072054.1	n/a
Location (UCSC)	Chr 17: 63.92 – 63.92 Mb	n/a
PubMed search	[1]	n/a
Wikidata

Somatotropin is a protein that in humans is encoded by the GH1 gene.^[2]

The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones that play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation, an arrangement thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. This particular family member is expressed in the pituitary but not in placental tissue as is the case for the other four genes in the growth hormone locus. Mutations in or deletions of the gene lead to growth hormone deficiency and short stature.^[3]

See also

• Growth hormone

References

Further reading

PDB gallery
1a22: HUMAN GROWTH HORMONE BOUND TO SINGLE RECEPTOR  1axi: STRUCTURAL PLASTICITY AT THE HGH:HGHBP INTERFACE  1bp3: THE XRAY STRUCTURE OF A GROWTH HORMONE-PROLACTIN RECEPTOR COMPLEX  1hgu: HUMAN GROWTH HORMONE  1huw: THE CRYSTAL STRUCTURE OF AFFINITY-MATURED HUMAN GROWTH HORMONE AT 2 ANGSTROMS RESOLUTION  1hwg: 1:2 COMPLEX OF HUMAN GROWTH HORMONE WITH ITS SOLUBLE BINDING PROTEIN  1hwh: 1:1 COMPLEX OF HUMAN GROWTH HORMONE MUTANT G120R WITH ITS SOLUBLE BINDING PROTEIN  1kf9: PHAGE DISPLAY DERIVED VARIANT OF HUMAN GROWTH HORMONE COMPLEXED WITH TWO COPIES OF THE EXTRACELLULAR DOMAIN OF ITS RECEPTOR  3hhr: HUMAN GROWTH HORMONE AND EXTRACELLULAR DOMAIN OF ITS RECEPTOR: CRYSTAL STRUCTURE OF THE COMPLEX