HARS2

HARS2
Identifiers
Aliases HARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial
External IDs MGI: 1918041 HomoloGene: 40819 GeneCards: HARS2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

23438

70791

Ensembl

ENSG00000112855

ENSMUSG00000019143

UniProt

P49590

Q99KK9

RefSeq (mRNA)

NM_001278731
NM_001278732
NM_012208

NM_080636
NM_001305627

RefSeq (protein)

NP_001265660.1
NP_001265661.1
NP_036340.1

NP_542367.1

Location (UCSC) Chr 5: 140.69 – 140.7 Mb Chr 18: 36.78 – 36.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.[3][4]

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes share a bidirectional promoter.[4]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. O'Hanlon TP, Raben N, Miller FW (Jun 1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS". Biochem Biophys Res Commun. 210 (2): 556–66. doi:10.1006/bbrc.1995.1696. PMID 7755634.
  4. 1 2 "Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)".

Further reading


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