HELLS

HELLS
Identifiers
Aliases HELLS, LSH, PASG, SMARCA6, Nbla10143, ICF4, helicase, lymphoid-specific
External IDs MGI: 106209 HomoloGene: 50037 GeneCards: HELLS
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

3070

15201

Ensembl

ENSG00000119969

ENSMUSG00000025001

UniProt

Q9NRZ9
Q76H82

Q60848

RefSeq (mRNA)

NM_008234

RefSeq (protein)

NP_032260.2

Location (UCSC) Chr 10: 94.5 – 94.61 Mb Chr 19: 38.93 – 38.97 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Lymphoid-specific helicase is an enzyme that in humans is encoded by the HELLS gene.[3][4][5]

This gene encodes a lymphoid-specific helicase. Other helicases function in processes involving DNA strand separation, including replication, repair, recombination, and transcription. This protein is thought to be involved with cellular proliferation and may play a role in leukemogenesis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Geiman TM, Durum SK, Muegge K (Feb 1999). "Characterization of gene expression, genomic structure, and chromosomal localization of Hells (Lsh)". Genomics. 54 (3): 477–83. doi:10.1006/geno.1998.5557. PMID 9878251.
  4. Lee DW, Zhang K, Ning ZQ, Raabe EH, Tintner S, Wieland R, Wilkins BJ, Kim JM, Blough RI, Arceci RJ (Aug 2000). "Proliferation-associated SNF2-like gene (PASG): a SNF2 family member altered in leukemia". Cancer Res. 60 (13): 3612–22. PMID 10910076.
  5. 1 2 "Entrez Gene: HELLS helicase, lymphoid-specific".

Further reading


This article is issued from Wikipedia - version of the 5/31/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.