HLA-B44


HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B44
Alleles	B*4401, 4402, 4403 . .
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

HLA-B44 (B44) is an HLA-B serotype. The serotype identifies the B*44 gene-allele protein products of HLA-B.^[1]

Further information: HLA-serotype tutorial

B44 is a split antigen of the broad antigen B12, and is a sister type of B45.

Serotype

Serotypes B44, B12, and B45 recognition of the
HLA B*44 gene products^[2]
B*44	B44	B12	B45	Sample
allele	%	%	%	size (N)
*4402	98			6959
*4403	94			2854
*4404	65			42
*4405	92			130
*4406	44			9
B4401 was shown to be B4402 after errors corrected.
Alleles link-out to IMGT/HLA Database at EBI

Disease

HLA-B44 increases recurrent sinopulmonary infections.^[3] Protective effects: HLA-B44 appears to be protective against autoimmune lymphoproliferative syndrome in patients with C95 defect (ALPS type Ia).^[4] B44 may be a cofactor in ankylosing spondylitis^[5]

References

↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens. 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
↑ derived from IMGT/HLA
↑ Johnston DT, Mehaffey G, Thomas J, et al. (June 2006). "Increased frequency of HLA-B44 in recurrent sinopulmonary infections (RESPI)". Clin. Immunol. 119 (3): 346–50. doi:10.1016/j.clim.2006.02.001. PMID 16542878.
↑ Vacek MM, Schäffer AA, Davis J, et al. (January 2006). "HLA B44 is associated with decreased severity of autoimmune lymphoproliferative syndrome in patients with CD95 defects (ALPS type Ia)". Clin. Immunol. 118 (1): 59–65. doi:10.1016/j.clim.2005.09.006. PMID 16257267.
↑ Purrmann J, Zeidler H, Bertrams J, et al. (November 1988). "HLA antigens in ankylosing spondylitis associated with Crohn's disease. Increased frequency of the HLA phenotype B27,B44". J. Rheumatol. 15 (11): 1658–61. PMID 3266250.

HLA-B serotypes and allele groups

HLA-B B5 B51 B52 B7 B8 B12 B44 B45 B13 B14 B64 B65 B15 B62 B63 B70 B71 B72 B75 B76 B77 B16 B38 B39 B17 B57 B58 B18 B21 B49 B50 B22 B54 B55 B56 B27 B35 B37 B40 B60 B61 B41 B42 B46 B47 B48 B53 B59 B67 B73 B78 B81 B82 B83

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