HMG-box

HMG (high mobility group) box

NMR structure of the HMG-box domain of the LEF1 protein (rainbow colored, N-terminus = blue, C-terminus = red) complexed with DNA (brown) based on the PDB: 2LEF coordinates.
Identifiers
Symbol PF00505
Pfam PF00505
InterPro IPR009071
SCOP 1hsm
SUPERFAMILY 1hsm

In molecular biology, the HMG-box (high mobility group box) is a protein domain which is involved in DNA binding.[1]

Structure

The structure of the HMG-box domain contains three alpha helices separated by loops (see figure to the right).[2]

Function

HMG-box containing proteins only bind non-B-type DNA conformations (kinked or unwound) with high affinity.[1] HMG-box domains are found in high mobility group proteins, which are involved in the regulation of DNA-dependent processes such as transcription, replication, and DNA repair, all of which require changing the conformation of chromatin.[2]

References

  1. 1 2 Stros M, Launholt D, Grasser KD (October 2007). "The HMG-box: a versatile protein domain occurring in a wide variety of DNA-binding proteins". Cell. Mol. Life Sci. 64 (19–20): 2590–606. doi:10.1007/s00018-007-7162-3. PMID 17599239.
  2. 1 2 Thomas JO (August 2001). "HMG1 and 2: architectural DNA-binding proteins". Biochem. Soc. Trans. 29 (Pt 4): 395–401. doi:10.1042/BST0290395. PMID 11497996.

External links


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