Historical annual reformulations of the influenza vaccine
| Influenza (Flu) |
|---|
 |
| Types |
| Vaccines |
| Treatment |
| Pandemics |
| Outbreaks |
| See also |
Since 1999, the World Health Organization has issued annual recommendations for influenza vaccine formulations. One reformulation of the influenza vaccine is for the Northern Hemisphere, and the other is for the Southern Hemisphere.[1] Both recommendations are trivalent, i.e. featuring three strains.
Since the 2012–13 season, the WHO recommendations have also included the formulation of an annual quadrivalent vaccine, featuring an additional B-strain.
Northern Hemisphere recommended strains
The following is a list of WHO recommended strains for the Northern Hemisphere influenza season.
| NH winter season | H1N1 | H3N2 | B-strain | additional B-strain for QIV |
|---|---|---|---|---|
| November 1998–April 1999[2] | A/Beijing/262/95(H1N1)-like virus | A/Sydney/5/97(H3N2)-like virus | B/Beijing/184/93-like virus | N/A |
| November 1999–April 2000[3] | A/Beijing/262/95 (H1N1)-like virus | A/Sydney/5/97 (H3N2)-like virus | B/Beijing/184/93-like virus or B/Shangdong/7/97-like virus | N/A |
| 2000–2001[4] | A/New Caledonia/20/99 (H1N1)-like virus | A/Moscow/10/99 (H3N2)-like virus | B/Beijing/184/93-like virus | N/A |
| 2001–2002[5] | A/New Caledonia/20/99(H1N1)-like virus | A/Moscow/10/99(H3N2)-like virus | B/Sichuan/379/99-like virus | N/A |
| 2002–2003[6] | A/New Caledonia/20/99(H1N1)-like virus | A/Moscow/10/99(H3N2)-like virus | B/Hong Kong/330/2001-like virus | N/A |
| 2003–2004[7] | A/New Caledonia/20/99(H1N1)-like virus | A/Moscow/10/99(H3N2)-like virus | B/Hong Kong/330/2001-like virus | N/A |
| 2004-2005[8] | A/New Caledonia/20/99(H1N1)-like virus | A/Fujian/411/2002(H3N2)-like virus | B/Shanghai/361/2002-like virus | N/A |
| 2005-2006[9] | A/New Caledonia/20/99(H1N1)-like virus | A/California/7/2004(H3N2)-like virus | B/Shanghai/361/2002-like virus | N/A |
| 2006-2007[10] | A/New Caledonia/20/99(H1N1)-like | A/Wisconsin/67/2005 (H3N2)-like virus | B/Malaysia/2506/2004-like virus | N/A |
| 2007-2008[11] | A/Solomon Islands/3/2006 (H1N1)-like virus | A/Wisconsin/67/2005 (H3N2)-like virus | B/Malaysia/2506/2004-like virus | N/A |
| 2008-2009[12] | A/Brisbane/59/2007 (H1N1)-like virus | A/Brisbane/10/2007 (H3N2)-like virus | B/Florida/4/2006-like virus | N/A |
| 2009-2010[13] | A/Brisbane/59/2007 (H1N1)-like virus | A/Brisbane/10/2007 (H3N2)-like virus | B/Brisbane/60/2008-like virus | N/A |
| 2010-2011[14] | A/California/7/2009 (H1N1)-like virus | A/Perth/16/2009 (H3N2)-like virus | B/Brisbane/60/2008-like virus | N/A |
| 2011-2012[15] | A/California/7/2009 (H1N1)-like virus | A/Perth/16/2009 (H3N2)-like virus | B/Brisbane/60/2008-like virus | N/A |
| 2012-2013[16] | A/California/7/2009 (H1N1)pdm09[note 1]-like virus[17] | A/Victoria/361/2011 (H3N2)-like virus | B/Wisconsin/1/2010-like virus | B/Brisbane/60/2008-like virus |
| 2013-2014[18] | A/California/7/2009 (H1N1)pdm09[note 1]-like virus | A(H3N2) virus antigenically like the cell-propagated prototype virus A/Victoria/361/2011[note 2] | B/Massachusetts/2/2012-like virus | B/Brisbane/60/2008-like virus |
| 2014-2015[19] | A/California/7/2009 (H1N1)pdm09[note 1]-like virus | A/Texas/50/2012 (H3N2)-like virus[note 3] | B/Massachusetts/2/2012-like virus | B/Brisbane/60/2008-like virus |
| 2015-2016[20] | A/California/7/2009 (H1N1)pdm09[note 1]-like virus | A/Switzerland/9715293/2013 (H3N2)-like virus | B/Phuket/3073/2013-like virus | B/Brisbane/60/2008-like virus |
| 2016-2017[21] | A/California/7/2009 (H1N1)pdm09[note 1]-like virus | A/Hong Kong/4801/2014 (H3N2)-like virus | B/Brisbane/60/2008-like virus | B/Phuket/3073/2013-like virus |
Southern hemisphere recommended strains
The following is a list of WHO recommended strains for the southern hemisphere influenza season.
| SH winter season | H1N1 | H3N2 | B-strain | additional B-strain for QIV |
|---|---|---|---|---|
| 1999[22] | A/Beijing/262/95(H1N1)-like virus | A/Sydney/5/97(H3N2)-like virus | B/Beijing/184/93-like virus | N/A |
| May–October 2000[23] | A/New Caledonia/20/99 (H1N1)-like virus | A/Moscow/10/99 (H3N2)-like virus | B/Beijing/184/93-like virus or B/Shangdong/7/97-like virus | N/A |
| May–October 2001[24] | A/New Caledonia/20/99 (H1N1)-like virus | A/Moscow/10/99 (H3N2)-like virus | B/Sichuan/379/99-like virus | N/A |
| 2002[25] | A/New Caledonia/20/99(H1N1)-like virus | A/Moscow/10/99(H3N2)-like virus | B/Sichuan/379/99-like virus | N/A |
| 2003[26] | A/New Caledonia/20/99(H1N1)-like virus | A/Moscow/10/99(H3N2)-like virus | B/Hong Kong/330/2001-like virus | N/A |
| 2004[27] | A/New Caledonia/20/99(H1N1)-like virus | A/Fujian/411/2002(H3N2) - like virus | B/Hong Kong/330/2001-like virus | N/A |
| 2005[28] | A/New Caledonia/20/99(H1N1)-like virus | A/Wellington/1/2004(H3N2)-like virus | B/Shanghai/361/2002-like virus | N/A |
| 2006[29] | A/New Caledonia/20/99(H1N1)-like virus | A/California/7/2004(H3N2)-like virus | B/Malaysia/2506/2004-like virus | N/A |
| 2007[30] | A/New Caledonia/20/99(H1N1)-like | A/Wisconsin/67/2005 (H3N2)-like virus | B/Malaysia/2506/2004-like virus | N/A |
| 2008[31] | A/Solomon Islands/3/2006 (H1N1)-like virus | A/Brisbane/10/2007 (H3N2)-like virus | B/Florida/4/2006-like virus | N/A |
| 2009[32] | A/Brisbane/59/2007 (H1N1)-like virus | A/Brisbane/10/2007 (H3N2)-like virus | B/Florida/4/2006-like virus | N/A |
| 2010[33] | A/California/7/2009 (H1N1)-like virus | A/Perth/16/2009 (H3N2)-like virus | B/Brisbane/60/2008-like virus | N/A |
| 2011[34] | A/California/7/2009 (H1N1)-like virus | A/Perth/16/2009 (H3N2)-like virus | B/Brisbane/60/2008-like virus | N/A |
| 2012[35] | A/California/7/2009 (H1N1)pdm09[note 1]-like virus[17] | A/Perth/16/2009 (H3N2)-like virus | B/Brisbane/60/2008-like virus | N/A |
| 2013[36] | A/California/7/2009 (H1N1)pdm09-like virus | A/Victoria/361/2011 (H3N2)-like virus | B/Wisconsin/1/2010-like virus | B/Brisbane/60/2008-like virus |
| 2014[37] | A/California/7/2009 (H1N1)pdm09-like virus | A/Texas/50/2012 (H3N2)-like virus[note 3] | B/Massachusetts/2/2012-like virus | B/Brisbane/60/2008-like virus |
| 2015[38] | A/California/7/2009 (H1N1)pdm09-like virus | A/Switzerland/9715293/2013 (H3N2)-like virus | B/Phuket/3073/2013-like virus | B/Brisbane/60/2008-like virus |
| 2016[39] | A/California/7/2009 (H1N1)pdm09-like virus | A/Hong Kong/4801/2014 (H3N2)-like virus | B/Brisbane/60/2008-like virus | B/Phuket/3073/2013-like virus |
| 2017[40] | A/Michigan/45/2015 (H1N1)pdm09-like virus | A/Hong Kong/4801/2014 (H3N2)-like virus | B/Brisbane/60/2008-like virus | B/Phuket/3073/2013-like virus |
Notes
- 1 2 3 4 5 6 (H1N1)pdm09 is newer nomenclature for the 2009 pandemic H1N1 virus, not a different strain.
- ↑ It is recommended that A/Texas/50/2012 is used as the A(H3N2) vaccine component because of antigenic changes in earlier A/Victoria/361/2011-like vaccine viruses (such as IVR-165) resulting from adaptation to propagation in eggs.
- 1 2 A/Texas/50/2012 is an A(H3N2) virus that following adaptation to growth in eggs has maintained antigenic properties similar to the majority of recently circulating cell-propagated A(H3N2) viruses including A/Victoria/361/2011
See also
References
- ↑ WHO Report on Global Surveillance of Epidemic-prone Infectious Diseases (pdf)
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere November 1998-April 1999". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: November 1999 to April 2000". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2000-2001". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2001-2002". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2002-2003". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2003-2004". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2004-2005". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2005-2006". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2006-2007". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2007-2008". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2008-2009". WHO. Retrieved 14 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Northern hemisphere: 2009-2010". WHO. Retrieved 14 June 2012.
- ↑ "Recommended viruses for influenza vaccines for use in the 2010-2011 northern hemisphere influenza season". WHO. Retrieved 14 June 2012.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2011-2012 northern hemisphere influenza season". WHO. Retrieved 14 June 2012.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2012-2013 northern hemisphere influenza season". WHO. Retrieved 14 June 2012.
- 1 2 "Standardization of terminology of the pandemic A(H1N1) 2009 virus" (PDF). WHO. Retrieved 14 June 2012.
- ↑ "20 February 2013 Page 1 of 21 Recommended composition of influenza virus vaccines for use in the 2013-2014 northern hemisphere influenza season" (PDF). WHO. Retrieved 22 February 2013.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2014-15 northern hemisphere influenza season". WHO. Retrieved 20 February 2014.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2015-16 northern hemisphere influenza season". WHO. Retrieved 2 March 2015.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2016-17 northern hemisphere influenza season". WHO. Retrieved 19 May 2016.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere 1999". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: May–October 2000". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: May–October 2001". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2002". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2003". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2004". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2005". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2006". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2007". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2008". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2009". WHO. Retrieved 22 June 2012.
- ↑ "Recommendations for Influenza Vaccine Composition Southern hemisphere: 2010". WHO. Retrieved 22 June 2012.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2011 southern hemisphere influenza season". WHO. Retrieved 22 June 2012.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2012 southern hemisphere influenza season". WHO. Retrieved 22 June 2012.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2013 influenza season" (PDF). WHO. Retrieved 18 October 2012.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2014 southern hemisphere influenza season". WHO. Retrieved 30 September 2013.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2015 southern hemisphere influenza season". WHO. Retrieved 2 October 2014.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2016 southern hemisphere influenza season". WHO. Retrieved 30 November 2015.
- ↑ "Recommended composition of influenza virus vaccines for use in the 2017 southern hemisphere influenza season". WHO. 29 September 2016.
This article is issued from Wikipedia - version of the 10/22/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.