Totomycin
Clinical data | |
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ATC code | none |
Identifiers | |
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Synonyms | Hygromycin A, Homomycin |
CAS Number | 6379-56-2 |
PubChem (CID) | 6433481 |
ChemSpider | 4938630 |
Chemical and physical data | |
Formula | C23H29NO12 |
Molar mass | 511.475 g/mol |
3D model (Jmol) | Interactive image |
Melting point | 110 to 112 °C (230 to 234 °F) (decomp.) |
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Totomycin (also known as hygromycin A) is an aminoglycoside antibiotic produced by Streptomyces hygroscopicus, first described in the 1950s. The bacteria source is similar to that of hygromycin B from which the name of the compound was derived.
History
Hygromycin A was discovered in a soil sample from a forest near Indianapolis, Indiana in 1953 by Waksman and Henrici.[1] Identification and structure of totomycin wasn't determined until 1957.
Antibiotic activity
The strongest antibiotic activity of totomycin is against Staphylococcus haemolyticus in which growth was inhibited by concentrations of 2 µg/mL. Other gram-positive and gram-negative sensitive to totomycin are inhibited by concentrations from 16 to 31 µg/mL.[2]
Total synthesis
Totomycin has been a successful target in total synthesis since 1989.[3]