Kaptin (actin binding protein)

KPTN
Identifiers
Aliases	KPTN, 2E4, MRT41, kaptin (actin binding protein), kaptin, actin binding protein
External IDs	MGI: 1890380 HomoloGene: 5127 GeneCards: KPTN
Gene ontology Molecular function • actin binding Cellular component • actin cytoskeleton • cytoplasm • growth cone • perinuclear region of cytoplasm • cell projection • nucleus • stereocilium • microtubule organizing center Biological process • movement of cell or subcellular component • sensory perception of sound • actin filament organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11133	70394
Ensembl	ENSG00000118162	ENSMUSG00000006021
UniProt	Q9Y664	Q8VCX6
RefSeq (mRNA)	NM_001291296 NM_007059	NM_133727
RefSeq (protein)	NP_001278225.1 NP_008990.2	n/a
Location (UCSC)	Chr 19: 47.48 – 47.48 Mb	Chr 7: 16.12 – 16.13 Mb
PubMed search	[1]	[2]
Wikidata

Kaptin is a protein that in humans is encoded by the KPTN gene.^[3][4]

Model organisms

Model organisms have been used in the study of KPTN function. A conditional knockout mouse line, called Kptn^{tm1a(EUCOMM)Wtsi[14][15]} was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.^[16][17][18]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[12][19] Twenty two tests were carried out on mutant mice and six significant abnormalities were observed.^[12] Homozygous mutant mice had hyperalbuminemia, decreased mature B cell numbers and increased susceptibility to bacterial infection. Female mice also had increased body weight, body fat and impaired glucose tolerance.^[12]

References

Further reading