- Michael Alldredge as Don Horton (3 episodes, season 4) and Steve Jackson (4 episodes, season 8) and Ray King (2 episodes, season 14)
- Barbara Babcock as Liz Craig (16 episodes, seasons 2–5)
- Stephanie Blackmore as Serena Wald (20 episodes, seasons 3, 5–8, 11 and 13)
- Martin E. Brooks as Edgar Randolph (10 episodes, seasons 7–8)
- James L. Brown as Sergeant Harry McSween (41 episodes, seasons 2–12)
- Burke Byrnes as Pete Adams (9 episodes, seasons 8–9)
- George Chakiris as Nicholas (11 episodes, season 9)
- Lois Chiles as Holly Harwood (25 episodes, seasons 6–7)
- Jeff Cooper as Dr. Simon Ellby (19 episodes, seasons 3–4)
- Glenn Corbett as Paul Morgan (18 episodes, seasons 7 and 9–11)
- Karlene Crockett as Muriel Gillis (12 episodes, seasons 2–6)
- Joel Fabiani as Alex Ward (8 episodes, season 4)
- Fern Fitzgerald as Marilee Stone (73 episodes, seasons 2–13)
- Tom Fuccello as Dave Culver (35 episodes, seasons 3–6, 8, 10–11 and 13–14)
- Jeri Gaile as Rose Daniels McKay (20 episodes, seasons 12–14)
- Jonathan Goldsmith as Joe Smith (3 episodes, season 5) and Bruce Harvey (16 episodes, seasons 10 and 12)
- Laurence Haddon as Franklin Horner (17 episodes, seasons 4–6 and 9–10)
- Joshua Harris as Christopher Ewing (112 episodes, seasons 9–14)
- Art Hindle as Jeff Farraday (11 episodes, season 5)
- Alice Hirson as Mavis Anderson (26 episodes, seasons 6–7 and 10–11)
- Deirdre Imershein as Jory Taylor (8 episodes, season 14)
- Barry Jenner as Dr. Jerry Kenderson (25 episodes, seasons 7–9)
- Omri Katz as John Ross Ewing III (152 episodes, seasons 7–14)
- Kenneth Kimmins as Thornton McLeish (11 episodes, seasons 6–7)
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- Fredric Lehne as Eddie Cronin (19 episodes, season 8)
- Arthur Malet as Mr. Forest (3 episodes, season 5) and Ryan (5 episodes, seasons 13–14)
- Shalane McCall as Charlie Wade (102 episodes, seasons 7–11)
- Derek McGrath as Oswald Valentine (15 episodes, seasons 10–11)
- Jim McMullan as Andrew Dowling (14 episodes, season 10)
- Bill Morey as Judge (1 episode, season 5) and Leo Wakefield (11 episodes, season 7–8 and 11)
- Dennis Patrick as Vaughn Leland (19 episodes, seasons 3, 5 and 7–8)
- J. Eddie Peck as Tommy McKay (13 episodes, seasons 12–13)
- George O. Petrie as Harv Smithfield (54 episodes, seasons 3–14)
- Ben Piazza as Walt Discoll (11 episodes, season 6)
- J.A. Preston as Leo Daltry (9 episodes, season 10)
- Dennis Redfield as Roger Larson (12 episodes, season 5)
- Kate Reid as Lil Trotter (17 episodes, seasons 6–7 and 9)
- Deborah Rennard as Sly Lovegren (188 episodes, seasons 5–14)
- Don Starr as Jordan Lee (89 episodes, seasons 2–14)
- Amy Stock as Lisa Alden (16 episodes, season 11)
- Christopher Stone as Dave Stratton (9 episodes, seasons 4 and 8)
- Deborah Tranelli as Phyllis Wapner (147 episodes, seasons 4–14)
- Merete Van Kamp as Grace Van Owen (17 episodes, season 9)
- Hunter von Leer as B.D. Calhoun (10 episodes, season 10)
- Michael Wilding as Alex Barton (9 episodes, season 13)
- Ray Wise as Blair Sullivan (8 episodes, seasons 5–6)
- Morgan Woodward as Marvin "Punk" Anderson (55 episodes, seasons 4–11)
- Gretchen Wyler as Dr. Dagmara Conrad (8 episodes, season 5)
- Kathleen York as Betty (10 episodes, season 8)
- John Zaremba as Dr. Harlen Danvers (13 episodes, seasons 2–3 and 5–10)
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