MFN1

MFN1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases MFN1, hfzo1, hfzo2, mitofusin 1
External IDs MGI: 1914664 HomoloGene: 11481 GeneCards: MFN1
Orthologs
Species Human Mouse
Entrez

55669

67414

Ensembl

ENSG00000171109

ENSMUSG00000027668

UniProt

Q8IWA4

Q811U4

RefSeq (mRNA)

NM_017927
NM_033540

NM_024200

RefSeq (protein)

NP_284941.2

NP_077162.2

Location (UCSC) Chr 3: 179.35 – 179.39 Mb Chr 3: 32.53 – 32.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Mitofusin-1 is a protein that in humans is encoded by the MFN1 gene.[3][4][5]

The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Adams MD, Kerlavage AR, Fields C, Venter JC (Sep 1993). "3,400 new expressed sequence tags identify diversity of transcripts in human brain". Nat Genet. 4 (3): 256–67. doi:10.1038/ng0793-256. PMID 8358434.
  4. Santel A, Fuller MT (Feb 2001). "Control of mitochondrial morphology by a human mitofusin". J Cell Sci. 114 (Pt 5): 867–74. PMID 11181170.
  5. 1 2 "Entrez Gene: MFN1 mitofusin 1".

Further reading


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