MICAL2

MICAL2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E9K

Identifiers

MICAL2, MICAL-2, MICAL2PV1, MICAL2PV2, microtubule associated monooxygenase, calponin and LIM domain containing 2

External IDs

MGI: 2444947 HomoloGene: 8760 GeneCards: MICAL2

Gene ontology
Molecular function	• oxidoreductase activity • actin binding • oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen • zinc ion binding • FAD binding • NADPH:sulfur oxidoreductase activity • metal ion binding • monooxygenase activity
Cellular component	• nucleus
Biological process	• heart looping • actin filament depolymerization • heart development • sulfur oxidation • positive regulation of transcription via serum response element binding • oxidation-reduction process • cytoskeleton organization
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


9645


320878


ENSG00000133816


ENSMUSG00000038244


O94851


Q8BML1

RefSeq (mRNA)

NM_001282663 NM_001282664 NM_001282665 NM_001282666 NM_001282667
NM_001282668 NM_014632


NM_001193305 NM_177282

RefSeq (protein)

NP_001269592.1 NP_001269593.1 NP_001269594.1 NP_001269595.1 NP_001269596.1
NP_055447.1


NP_001180234.1 NP_796256.1

Location (UCSC)

Chr 11: 12.09 – 12.26 Mb

Chr 7: 112.23 – 112.36 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene.^[3]^[4]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
↑ "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Ashida S, Furihata M, Katagiri T, et al. (2006). "Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression.". Clin. Cancer Res. 12 (9): 2767–73. doi:10.1158/1078-0432.CCR-05-1995. PMID 16675569.

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