MIR194-1
MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.[2]
Function
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.[2]
References
Further reading
- Sundaram P, Hultine S, Smith LM, Dews M, Fox JL, Biyashev D, Schelter JM, Huang Q, Cleary MA, Volpert OV, Thomas-Tikhonenko A (Dec 2011). "p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers". Cancer Research. 71 (24): 7490–501. doi:10.1158/0008-5472.CAN-11-1124. PMC 3242824
. PMID 22028325.
- Dong P, Kaneuchi M, Watari H, Hamada J, Sudo S, Ju J, Sakuragi N (2011). "MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1". Molecular Cancer. 10: 99. doi:10.1186/1476-4598-10-99. PMC 3173388. PMID 21851624.
- Song Y, Zhao F, Wang Z, Liu Z, Chiang Y, Xu Y, Gao P, Xu H (Jul 2012). "Inverse association between miR-194 expression and tumor invasion in gastric cancer". Annals of Surgical Oncology. 19 Suppl 3: S509–17. doi:10.1245/s10434-011-1999-2. PMID 21845495.
- Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T (Feb 2003). "New microRNAs from mouse and human". Rna. 9 (2): 175–9. doi:10.1261/rna.2146903. PMC 1370382. PMID 12554859.
- Xu J, Kang Y, Liao WM, Yu L (2012). "MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5". PLOS ONE. 7 (3): e31861. doi:10.1371/journal.pone.0031861. PMC 3291608. PMID 22396742.
- Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM (Oct 2010). "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development". Cancer Cell. 18 (4): 367–81. doi:10.1016/j.ccr.2010.09.005. PMC 3561766. PMID 20951946.
- Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ (Oct 2003). "Reduced accumulation of specific microRNAs in colorectal neoplasia". Molecular Cancer Research. 1 (12): 882–91. PMID 14573789.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.