Morbidity and Mortality Weekly Report

The Morbidity and Mortality Weekly Report is a weekly epidemiological digest for the United States published by the Centers for Disease Control and Prevention (CDC). It is the main vehicle for publishing public health information and recommendations that have been received by the CDC from state health departments. Material published in the report is in the public domain and may be reprinted without permission.^[1] As of 2015, the journal's editor-in-chief is Sonja Rasmussen.^[2]

As noted in the sequel, some single reports have evoked media interest also outside health and medical contexts. However, many reports are parts of series, providing consistent long-terms statistics, and also indicating trend changes. Such a standing report section is the "Notifiable Diseases and Mortality Tables", which reports deaths by disease and state, and city for city, for 122 large cities. As another example, there are more than a hundred items about West Nile virus infections, since the 1999 outbreak of the disease in the US. In the years 2001-2005, there were weekly updates of the WNV situation, during the warm seasons.^[3]

Notable articles

• The spread of hepatitis A among attendees of jam band concert tours (September 2003).^[4][5]
• Low concerns for risks of elevated blood levels of lead in Washington, DC (April 2004).^[6] The article was notable and later criticized^[7] for not emphasizing the risks, and now is available together with two amending "notices to the readers" by CDC from 2010.
• Several dozen deaths in teens participating in what is called the "choking game" (February 2008)^[8]
• A report about the elevated death rate among fisherman in the Pacific Northwest (April 2008)^[9]
• Improvements in public health after the implementation of municipal smoking bans (January 2009)^[10]
• The initial reports of a novel swine flu virus which led to the 2009 flu pandemic (April 24, 2009)^[11]

First report of AIDS

Five cases of Pneumocystis carinii pneumonia (PCP) were reported in what turned out to be the first reporting of AIDS in the medical literature (June 5, 1981).^[12] Los Angeles-based general practitioner Joel Weisman and immunologist Michael S. Gottlieb of the UCLA Medical Center had encountered a series of gay male patients with symptoms that appeared to be immune system disorders including significant loss of weight and swollen lymph nodes, accompanied by fever and rashes, in addition to two patients with chronic diarrhea, depressed white blood cell counts and fungal infections. Gottlieb diagnosed these and a number of his other patients as having pneumocystis pneumonia. A report they jointly wrote and published in the June 5, 1981, issue of Morbidity and Mortality Weekly Report, described their patients as "5 young men, all active homosexuals, [who] were treated for biopsy-confirmed Pneumocystis carinii pneumonia at 3 different hospitals in Los Angeles, California" of which "[t]wo of the patients died" by the time of the original report.^[13] This notice has been recognized as the first published report marking the official start of the AIDS pandemic and as "the first report on AIDS in the medical literature".^[14]

Drinking water lead report controversy

Background

Between 2001 and 2003, various tests showed that the lead content in drinking water in Washington DC more often than not was higher than 15 PPM (parts per million), which was the "action level" fixed by U.S. Environmental Protection Agency (EPA). Some of the tests were prompted by EPA's lead and copper rule, while others were conducted by professor Marc Edwards, while trying to find the causes of an increased rate of pinhole leaks in copper water pipes. He found some rather high values in a few households, sometimes exceeding 1250 PPM.^[15] From 2002 on the matter started to be noted by news media.^[16][17]

Lead is well known to have toxic effects, especially for embryos and small children. Even in small doses, lead poisoning may lead to e.g. permanent intelligence deficiencies and concentration difficulties.

Report details

On March 30, 2004, an "MMWR dispatch", Blood Lead Levels in Residents of Homes with Elevated Lead in Tap Water --- District of Columbia, 2004 was made available on the MMWR web site. It was then published by CDC as "MMWR Weekly, April 2, 2004 / 53(12);268-270".^[6] Its principal author was Mary Jean Brown, who was the head of the lead poisoning branch of CDC. The report "summarizes the results of the preliminary investigations, which indicated that the elevated water lead levels might have contributed to a small increase in blood lead levels (BLLs)". The report describes the background, and the various kinds of blood tests it employed, and explicitly states: "All blood tests were used in this analysis." There is no mention at all of any test results not being available, not even in the caveat section, where other potential sources of error are discussed.

The report concludes that the high amounts of lead in the drinking water may have led to a slight rise of the blood levels; however, it claimed that "no children were identified with BLLs >10µg/dL, even in homes with the highest water lead levels". It notes that 10 µg/dL was "CDC's BLL of concern for children" since 1991. The report also claimed that the average levels were sinking with time. On the other hand, the report found some cases of children with BLLs > 5 µg/dL; and also stated that actually "no safe BLL has been identified". Therefore, the report recommends that efforts should be made to eliminate lead in children's blood entirely, and in particular, that the authorities should take measures to ensure that the amount of lead in drinking water always should be less than 15 PPM.

The report does not in itself provide any recommendations to the ordinary Washington DC inhabitants, but it notes that the District of Columbia Department of Health has "recommended that young children and pregnant and breast-feeding women refrain from drinking unfiltered tap water".

Criticism of the report

The report later was strongly criticized, by Marc Edwards, some news media, and ultimately by the United States House Committee on Science, Space and Technology.

Marc Edwards initiated a study, which included investigating health aspects. At first, he was sponsored by EPA; but when they interrupted their support, he financed it out of his own pocket. He claimed that this study, employing raw data also available to the CDC study, had found clear evidence of a correlation between rather high amounts of lead in the water on the one hand, and rather high amounts of lead in the blood of children on the other. Specifically, there were cases known to him, of children with BBL clearly exceeding 10µg/dL; but these cases were absent from the material presented in the MMWR. Marc Edwards and pediatrician Dana Best of Children's National Medical Center in Washington, actually found a marked increase in high-level results from 2001 to 2004, among small children.^[18]

The results of Marc Edwards et al. came from analysis of the same raw data as those underlying the 2004 CDC report. In 2007, Edwards wrote to the CDC's associate director of science, James Stephens, questioning the report's conclusions and methodology, and the competence of its principal author. In 2008, Stephens answered him: "We have examined CDC's role in the study and have found no evidence of misconduct."^[18]

According to Salon, there was an evident dip in critical year 2003 (when the lead in the drinking water peaked), in the data present in the CDC files, there were test results for 15,755 children in 2002, only 9,765 children in 2003, and 18,038 children in 2004, At the time, Mary Jean Brown had questioned the dip, and had gotten the answer that it was due to a private laboratory not having reported the low values they had found. She had accepted the answer.^[18] Salon also claimed that the CDC had found a link between lead pipes and high childhood blood lead levels in the district in 2007, but had not publicized the study.^[18][19]

In 2009, the United States House of Representatives' Science and Technology Committee opened a congressional investigation into the 2004 CDC report.^[19] Investigators found that although the CDC and city health department reported dangerous lead levels in 193 children in 2003, the actual number was 486 according to records taken directly from the testing laboratories.^[19] In 2010, in their final report, the committee concluded that the CDC knowingly used flawed data in drafting the report, leading to "scientifically indefensible" claims in the 2004 paper.^[7] It also cited the CDC for failing to publicize later research showing that the harm was more serious than the 2004 report suggested.^[7]

Response to the criticism

The CDC did not withdraw the report, but in 2010 amended it with two "notices to the readers", with the following explanations. The CDC maintained that the report essentially is correct, but admitted that the presentation was misleading, as regards the absence of data, and as regards the claim that no children with BLL's above the alert threshold 10 µg/dL were found. That claim, they stated, "was misleading because it referred only to data from the cross-sectional study and did not reflect findings of concern from the separate longitudinal study that showed that children living in homes serviced by a lead water pipe were more than twice as likely as other DC children to have had a blood lead level ≥10 µg/dL". Moreover, the CDC emphasizes, that the original report did warn for negative effects on health of the BLL's it did report, did note that there are no safe known limits, and did demand actions for reducing the level of lead in drinking water. They also maintain, that the overall trend was towards sinking BLL's, even when the full data set is taken into consideration.^[6]

References

External links

• Official website