NME3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1ZS6

Identifiers

Aliases

NME3, DR-nm23, NDPK-C, NDPKC, NM23-H3, NM23H3, c371H6.2, NME/NM23 nucleoside diphosphate kinase 3

External IDs

MGI: 1930182 HomoloGene: 20562 GeneCards: NME3

Gene ontology
Molecular function	• kinase activity • nucleotide binding • transferase activity • protein binding • ATP binding • nucleoside diphosphate kinase activity • metal ion binding
Cellular component	• extracellular exosome • mitochondrion • intracellular
Biological process	• regulation of apoptotic process • UTP biosynthetic process • apoptotic process • pyrimidine nucleotide metabolic process • purine nucleotide metabolic process • CTP biosynthetic process • GTP biosynthetic process • nucleotide metabolic process • nucleoside diphosphate phosphorylation • phosphorylation • nucleoside triphosphate biosynthetic process
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


4832


79059

Ensembl


ENSG00000103024


ENSMUSG00000073435

UniProt


Q13232


Q9WV85

RefSeq (mRNA)


NM_002513


NM_019730

RefSeq (protein)


NP_002504.2


NP_062704.2

Location (UCSC)

Chr 16: 1.77 – 1.77 Mb

Chr 17: 24.9 – 24.9 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Nucleoside diphosphate kinase 3 is an enzyme that in humans is encoded by the NME3 gene.^[3]^[4]

Interactions

NME3 has been shown to interact with NME1^[5]^[6] and NME2.^[6]^[7]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B (April 1997). "Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family". Cancer Res. 57 (6): 1180–7. PMID 9067290.
↑ "Entrez Gene: NME3 non-metastatic cells 3, protein expressed in".
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
1 2 Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (September 2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
↑ Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Venturelli D, Martinez R, Melotti P, Casella I, Peschle C, Cucco C, Spampinato G, Darzynkiewicz Z, Calabretta B (1995). "Overexpression of DR-nm23, a protein encoded by a member of the nm23 gene family, inhibits granulocyte differentiation and induces apoptosis in 32Dc13 myeloid cells". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7435–9. doi:10.1073/pnas.92.16.7435. PMC 41354. PMID 7638209.
Negroni A, Venturelli D, Tanno B, Amendola R, Ransac S, Cesi V, Calabretta B, Raschellà G (2000). "Neuroblastoma specific effects of DR-nm23 and its mutant forms on differentiation and apoptosis". Cell Death Differ. 7 (9): 843–50. doi:10.1038/sj.cdd.4400720. PMID 11042679.
Daniels RJ, Peden JF, Lloyd C, Horsley SW, Clark K, Tufarelli C, Kearney L, Buckle VJ, Doggett NA, Flint J, Higgs DR (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Sheffler DJ, Kroeze WK, Garcia BG, Deutch AY, Hufeisen SJ, Leahy P, Brüning JC, Roth BL (2006). "p90 ribosomal S6 kinase 2 exerts a tonic brake on G protein-coupled receptor signaling". Proc. Natl. Acad. Sci. U.S.A. 103 (12): 4717–22. doi:10.1073/pnas.0600585103. PMC 1450237. PMID 16537434.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Carinci F, Arcelli D, Lo Muzio L, Francioso F, Valentini D, Evangelisti R, Volinia S, D'Angelo A, Meroni G, Zollo M, Pastore A, Ionna F, Mastrangelo F, Conti P, Tetè S (2007). "Molecular classification of nodal metastasis in primary larynx squamous cell carcinoma". Transl Res. 150 (4): 233–45. doi:10.1016/j.trsl.2007.03.011. PMID 17900511.

PDB gallery

1zs6: structure of human nucleoside-diphosphate kinase 3

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NME3

Interactions

References

Further reading