PIK3R2

PIK3R2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KT1, 2XS6, 3MTT, 3O5Z
Identifiers
Aliases	PIK3R2, MPPH, MPPH1, P85B, p85, p85-BETA, phosphoinositide-3-kinase regulatory subunit 2
External IDs	MGI: 1098772 HomoloGene: 3687 GeneCards: PIK3R2
Gene ontology Molecular function • phosphatidylinositol 3-kinase regulator activity • receptor tyrosine kinase binding • 1-phosphatidylinositol-3-kinase regulator activity • protein binding • protein heterodimerization activity • protein phosphatase binding • GTPase activator activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity • 1-phosphatidylinositol-3-kinase activity Cellular component • cytosol • phosphatidylinositol 3-kinase complex • nucleus Biological process • Fc-gamma receptor signaling pathway involved in phagocytosis • cellular glucose homeostasis • positive regulation of glucose import in response to insulin stimulus • response to endoplasmic reticulum stress • positive regulation of transcription factor import into nucleus • Fc-epsilon receptor signaling pathway • phosphatidylinositol phosphorylation • vascular endothelial growth factor receptor signaling pathway • regulation of autophagy • regulation of phosphatidylinositol 3-kinase activity • transport • cellular response to insulin stimulus • protein transport • phosphatidylinositol biosynthetic process • phosphatidylinositol 3-kinase signaling • T cell receptor signaling pathway • regulation of small GTPase mediated signal transduction • phosphatidylinositol-mediated signaling • leukocyte migration • positive regulation of transcription from RNA polymerase II promoter • signal transduction • insulin receptor signaling pathway • positive regulation of GTPase activity • regulation of phosphatidylinositol 3-kinase signaling • phosphatidylinositol-3-phosphate biosynthetic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5296	18709
Ensembl	ENSG00000105647	ENSMUSG00000031834
UniProt	O00459	O08908
RefSeq (mRNA)	NM_005027	NM_008841
RefSeq (protein)	NP_005018.1	NP_032867.2
Location (UCSC)	Chr 19: 18.15 – 18.17 Mb	Chr 8: 70.77 – 70.78 Mb
PubMed search	[1]	[2]
Wikidata

Phosphatidylinositol 3-kinase regulatory subunit beta is an enzyme that in humans is encoded by the PIK3R2 gene.^[3][4]

Interactions

PIK3R2 has been shown to interact with:

• CRKL^[5]
• Cbl gene,^[6][7]
• Epidermal growth factor,^[8]
• FYN,^[8]
• HER2/neu,^[8]
• Macrophage colony-stimulating factor,^[8] and
• PIK3CD.^[9]

Clinical relevance

PIK3R2 mutations were recently shown to be associated with polymicrogyria.^[10]

References

Further reading