PDE8B

PDE8B

Identifiers

PDE8B, ADSD, PPNAD3, phosphodiesterase 8B

External IDs

MGI: 2443999 HomoloGene: 2758 GeneCards: PDE8B

Genetically Related Diseases

hypothyroidisms^[1]

Targeted by Drug

dipyridamole^[2]

Gene ontology
Molecular function	• phosphoric diester hydrolase activity • hydrolase activity • 3',5'-cyclic-nucleotide phosphodiesterase activity • metal ion binding • 3',5'-cyclic-AMP phosphodiesterase activity
Cellular component	• cytosol • cellular component
Biological process	• cyclic nucleotide metabolic process • negative regulation of insulin secretion • cAMP catabolic process • signal transduction
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


8622


218461


ENSG00000113231


ENSMUSG00000021684


O95263


E9Q4S1

RefSeq (mRNA)


NM_001029851 NM_001029852 NM_001029853 NM_001029854 NM_003719


NM_001170669 NM_172263

RefSeq (protein)


NP_001025022.1 NP_001025023.1 NP_001025024.1 NP_001025025.1 NP_003710.1


n/a

Location (UCSC)

Chr 5: 77.21 – 77.43 Mb

Chr 13: 95.02 – 95.25 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B is an enzyme that in humans is encoded by the PDE8B gene.^[5]^[6]

References

↑ "Diseases that are genetically associated with PDE8B view/edit references on wikidata".
↑ "Drugs that physically interact with High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B view/edit references on wikidata".
↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Hayashi M, Matsushima K, Ohashi H, Tsunoda H, Murase S, Kawarada Y, Tanaka T (Nov 1998). "Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase". Biochem Biophys Res Commun. 250 (3): 751–6. doi:10.1006/bbrc.1998.9379. PMID 9784418.
↑ "Entrez Gene: PDE8B phosphodiesterase 8B".

Further reading

Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
Persani L, Borgato S, Lania A, et al. (2001). "Relevant cAMP-specific phosphodiesterase isoforms in human pituitary: effect of Gs(alpha) mutations". J. Clin. Endocrinol. Metab. 86 (8): 3795–800. doi:10.1210/jc.86.8.3795. PMID 11502813.
Hayashi M, Shimada Y, Nishimura Y, et al. (2002). "Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene". Biochem. Biophys. Res. Commun. 297 (5): 1253–8. doi:10.1016/S0006-291X(02)02371-9. PMID 12372422.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gamanuma M, Yuasa K, Sasaki T, et al. (2003). "Comparison of enzymatic characterization and gene organization of cyclic nucleotide phosphodiesterase 8 family in humans". Cell. Signal. 15 (6): 565–74. doi:10.1016/S0898-6568(02)00146-8. PMID 12681444.
Pérez-Torres S, Cortés R, Tolnay M, et al. (2003). "Alterations on phosphodiesterase type 7 and 8 isozyme mRNA expression in Alzheimer's disease brains examined by in situ hybridization". Exp. Neurol. 182 (2): 322–34. doi:10.1016/S0014-4886(03)00042-6. PMID 12895443.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

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