PEX3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3AJB, 3MK4

Identifiers

Aliases

PEX3, PBD10A, TRG18, peroxisomal biogenesis factor 3

External IDs

MGI: 1929646 HomoloGene: 2691 GeneCards: PEX3

Gene ontology
Molecular function	• protein dimerization activity • amino acid transmembrane transporter activity • protein binding • lipid binding
Cellular component	• integral component of membrane • cytosol • membrane • intracellular membrane-bounded organelle • peroxisomal membrane • peroxisome • nucleoplasm • protein complex • protein-lipid complex • endoplasmic reticulum • integral component of peroxisomal membrane
Biological process	• amino acid transmembrane transport • peroxisome organization • peroxisome membrane biogenesis • protein import into peroxisome membrane • transmembrane transport • xenophagy • positive regulation of defense response to virus by host
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


8504


56535

Ensembl


ENSG00000034693


ENSMUSG00000019809

UniProt


P56589 Q7Z6V3


Q9QXY9

RefSeq (mRNA)


NM_003630


NM_001164195 NM_019961

RefSeq (protein)


NP_003621.1


NP_064345.1

Location (UCSC)

Chr 6: 143.45 – 143.49 Mb

Chr 10: 13.52 – 13.55 Mb

PubMed search

^[1]

^[2]

Wikidata

View/Edit Human

View/Edit Mouse

Peroxisomal biogenesis factor 3 is a protein that in humans is encoded by the PEX3 gene.^[3]^[4]

Interactions

PEX3 has been shown to interact with PEX19.^[5]^[6]^[7]^[8]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Kammerer S, Holzinger A, Welsch U, Roscher AA (Jun 1998). "Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p". FEBS Letters. 429 (1): 53–60. doi:10.1016/S0014-5793(98)00557-2. PMID 9657383.
↑ "Entrez Gene: PEX3 peroxisomal biogenesis factor 3".
↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
↑ Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (Mar 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochemical and Biophysical Research Communications. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
↑ Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (Mar 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
↑ Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (Jul 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.

South ST, Gould SJ (Jan 1999). "Peroxisome synthesis in the absence of preexisting peroxisomes". The Journal of Cell Biology. 144 (2): 255–66. doi:10.1083/jcb.144.2.255. PMC 2132891. PMID 9922452.
Soukupova M, Sprenger C, Gorgas K, Kunau WH, Dodt G (Jun 1999). "Identification and characterization of the human peroxin PEX3". European Journal of Cell Biology. 78 (6): 357–74. doi:10.1016/S0171-9335(99)80078-8. PMID 10430017.
Muntau AC, Holzinger A, Mayerhofer PU, Gärtner J, Roscher AA, Kammerer S (Feb 2000). "The human PEX3 gene encoding a peroxisomal assembly protein: genomic organization, positional mapping, and mutation analysis in candidate phenotypes". Biochemical and Biophysical Research Communications. 268 (3): 704–10. doi:10.1006/bbrc.2000.2193. PMID 10679269.
Sacksteder KA, Jones JM, South ST, Li X, Liu Y, Gould SJ (Mar 2000). "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis". The Journal of Cell Biology. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
Ghaedi K, Tamura S, Okumoto K, Matsuzono Y, Fujiki Y (Jun 2000). "The peroxin pex3p initiates membrane assembly in peroxisome biogenesis". Molecular Biology of the Cell. 11 (6): 2085–102. doi:10.1091/mbc.11.6.2085. PMC 14905. PMID 10848631.
Muntau AC, Mayerhofer PU, Paton BC, Kammerer S, Roscher AA (Oct 2000). "Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G". American Journal of Human Genetics. 67 (4): 967–75. doi:10.1086/303071. PMC 1287898. PMID 10958759.
Ghaedi K, Honsho M, Shimozawa N, Suzuki Y, Kondo N, Fujiki Y (Oct 2000). "PEX3 is the causal gene responsible for peroxisome membrane assembly-defective Zellweger syndrome of complementation group G". American Journal of Human Genetics. 67 (4): 976–81. doi:10.1086/303086. PMC 1287899. PMID 10968777.
Fransen M, Wylin T, Brees C, Mannaerts GP, Van Veldhoven PP (Jul 2001). "Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences". Molecular and Cellular Biology. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. PMC 87101. PMID 11390669.
Mayerhofer PU, Kattenfeld T, Roscher AA, Muntau AC (Mar 2002). "Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly". Biochemical and Biophysical Research Communications. 291 (5): 1180–6. doi:10.1006/bbrc.2002.6568. PMID 11883941.
Fransen M, Brees C, Ghys K, Amery L, Mannaerts GP, Ladant D, Van Veldhoven PP (Mar 2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Molecular & Cellular Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
Muntau AC, Roscher AA, Kunau WH, Dodt G (Jul 2003). "The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis". European Journal of Cell Biology. 82 (7): 333–42. doi:10.1078/0171-9335-00325. PMID 12924628.
Muntau AC, Roscher AA, Kunau WH, Dodt G (2004). "Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET)". Advances in Experimental Medicine and Biology. 544: 221–4. doi:10.1007/978-1-4419-9072-3_27. PMID 14713233.
Fang Y, Morrell JC, Jones JM, Gould SJ (Mar 2004). "PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins". The Journal of Cell Biology. 164 (6): 863–75. doi:10.1083/jcb.200311131. PMC 2172291. PMID 15007061.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Matsuzono Y, Matsuzaki T, Fujiki Y (Sep 2006). "Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation". Journal of Cell Science. 119 (Pt 17): 3539–50. doi:10.1242/jcs.03100. PMID 16895967.

External links

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PEX3

Interactions

References

Further reading

External links