PHC3

PHC3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4PZN, 4PZO

Identifiers

PHC3, EDR3, HPH3, polyhomeotic homolog 3

External IDs

MGI: 2181434 HomoloGene: 69390 GeneCards: PHC3

Gene ontology
Molecular function	• DNA binding • zinc ion binding • protein binding • metal ion binding
Cellular component	• PcG protein complex • PRC1 complex • intracellular membrane-bounded organelle • nucleus • nucleoplasm • actin cytoskeleton
Biological process	• multicellular organism development • protein sumoylation
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse


80012


241915


ENSG00000173889


ENSMUSG00000037652


Q8NDX5


Q8CHP6

RefSeq (mRNA)


NM_001308116 NM_024947


NM_001165954 NM_001165955 NM_001165956 NM_153421

RefSeq (protein)


NP_001295045.1 NP_079223.3


NP_001159426.1 NP_700470.2

Location (UCSC)

Chr 3: 170.09 – 170.18 Mb

Chr 3: 30.9 – 30.97 Mb

PubMed search

^[1]

^[2]

View/Edit Human

View/Edit Mouse

Polyhomeotic-like protein 3 is a protein that in humans is encoded by the PHC3 gene.^[3]^[4]^[5]

References

↑ "Human PubMed Reference:".
↑ "Mouse PubMed Reference:".
↑ Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Aug 2002). "The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans". Mol Cell Biol. 22 (17): 6070–6078. doi:10.1128/MCB.22.17.6070-6078.2002. PMC 134016. PMID 12167701.
↑ Tonkin E, Hagan DM, Li W, Strachan T (Oct 2002). "Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family". Hum Genet. 111 (4–5): 435–442. doi:10.1007/s00439-002-0814-3. PMID 12384788.
↑ "Entrez Gene: PHC3 polyhomeotic homolog 3 (Drosophila)".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–1718. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–5396. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
Deshpande AM, Akunowicz JD, Reveles XT, et al. (2007). "PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors". Oncogene. 26 (12): 1714–1722. doi:10.1038/sj.onc.1209988. PMC 2691996. PMID 17001316.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article is issued from Wikipedia - version of the 6/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.