PIK3CG

PIK3CG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX, 4AOF, 4DK5, 4EZJ, 4EZK, 4EZL, 4F1S, 4FA6, 4FAD, 4FHJ, 4FHK, 4FJY, 4FJZ, 4FLH, 4FUL, 4G11, 4GB9, 4HLE, 4HVB, 4J6I, 4KZ0, 4KZC, 4PS3, 4PS7, 4PS8, 4URK, 4WWN, 4WWO, 4WWP, 4XX5, 4XZ4, 5EDS, 5G2N
Identifiers
Aliases	PIK3CG, PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
External IDs	MGI: 1353576 HomoloGene: 68269 GeneCards: PIK3CG
EC number	2.7.11.1
Targeted by Drug
dactolisib, idelalisib, ly-294002[1]
Gene ontology Molecular function • transferase activity • protein kinase activity • nucleotide binding • ephrin receptor binding • 1-phosphatidylinositol-3-kinase activity • 1-phosphatidylinositol-4-phosphate 3-kinase activity • kinase activity • protein serine/threonine kinase activity • protein binding • phosphatidylinositol 3-kinase activity • ATP binding • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • cytoplasm • phosphatidylinositol 3-kinase complex • membrane • plasma membrane • phosphatidylinositol 3-kinase complex, class IB • cytosol • mast cell granule Biological process • regulation of protein phosphorylation • G-protein coupled receptor signaling pathway • positive regulation of protein kinase B signaling • regulation of cell adhesion mediated by integrin • endocytosis • adaptive immune response • respiratory burst involved in defense response • positive regulation of MAP kinase activity • phosphorylation • immune system process • positive regulation of cytosolic calcium ion concentration • T cell chemotaxis • cytokine production • positive regulation of catalytic activity • secretory granule localization • dendritic cell chemotaxis • neutrophil chemotaxis • platelet activation • T cell proliferation • chemotaxis • protein phosphorylation • phosphatidylinositol-3-phosphate biosynthetic process • phosphatidylinositol phosphorylation • natural killer cell chemotaxis • angiogenesis • positive regulation of acute inflammatory response • phosphatidylinositol biosynthetic process • negative regulation of fibroblast apoptotic process • phosphatidylinositol 3-kinase signaling • negative regulation of triglyceride catabolic process • mast cell degranulation • inflammatory response • innate immune response • platelet aggregation • neutrophil extravasation • T cell activation • regulation of calcium ion transmembrane transport • cellular response to cAMP • hepatocyte apoptotic process • phosphatidylinositol-mediated signaling • negative regulation of cardiac muscle contraction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5294	30955
Ensembl	ENSG00000105851	ENSMUSG00000020573
UniProt	P48736	Q9JHG7
RefSeq (mRNA)	NM_001282426 NM_001282427 NM_002649	NM_001146200 NM_001146201 NM_020272
RefSeq (protein)	NP_001269355.1 NP_001269356.1 NP_002640.2	NP_001139672.1 NP_001139673.1 NP_064668.2
Location (UCSC)	Chr 7: 106.87 – 106.91 Mb	Chr 12: 32.17 – 32.21 Mb
PubMed search	[2]	[3]
Wikidata

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

Function

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.^[4]

Interactions

PIK3CG has been shown to interact with:

• BCR gene,^[5][6][7]
• KRAS,^[8]
• PIK3CD,^[9] and
• PIK3R5.^[10]

See also

• Class I PI 3-kinases
• p87PIKAP

References

Further reading

PDB gallery
1e7u: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE  1e7v: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE  1e8w: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE  1e8x: STRUCTURAL INSIGHTS INTO PHOSHOINOSITIDE 3-KINASE ENZYMATIC MECHANISM AND SIGNALLING  1e8y: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE  1e8z: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE  1e90: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE  1he8: RAS G12V - PI 3-KINASE GAMMA COMPLEX  2a4z: Crystal Structure of human PI3Kgamma complexed with AS604850  2a5u: Crystal Structure of human PI3Kgamma complexed with AS605240  2chw: A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110 ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-39  2chx: A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-90  2chz: A PHARMACOLOGICAL MAP OF THE PI3-K FAMILY DEFINES A ROLE FOR P110ALPHA IN SIGNALING: THE STRUCTURE OF COMPLEX OF PHOSPHOINOSITIDE 3-KINASE GAMMA WITH INHIBITOR PIK-93