PODXL

PODXL
Identifiers
Aliases PODXL, Gp200, PC, PCLP, PCLP-1, podocalyxin like
External IDs HomoloGene: 136790 GeneCards: PODXL
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

5420

n/a

Ensembl

ENSG00000128567

n/a

UniProt

O00592

n/a

RefSeq (mRNA)

NM_005397
NM_001018111

n/a

RefSeq (protein)

NP_001018121.1
NP_005388.2

n/a

Location (UCSC) Chr 7: 131.5 – 131.56 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Podocalyxin-like protein 1 is a protein that in humans is encoded by the PODXL gene.[2]

Function

This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin.[2]

Interactions

PODXL has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[3][4][5]

References

  1. "Human PubMed Reference:".
  2. 1 2 "Entrez Gene: PODXL podocalyxin-like".
  3. Meder D, Shevchenko A, Simons K, Füllekrug J (Jan 2005). "Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells". The Journal of Cell Biology. 168 (2): 303–13. doi:10.1083/jcb.200407072. PMC 2171597Freely accessible. PMID 15642748.
  4. Takeda T, McQuistan T, Orlando RA, Farquhar MG (Jul 2001). "Loss of glomerular foot processes is associated with uncoupling of podocalyxin from the actin cytoskeleton". The Journal of Clinical Investigation. 108 (2): 289–301. doi:10.1172/JCI12539. PMC 203027Freely accessible. PMID 11457882.
  5. Li Y, Li J, Straight SW, Kershaw DB (Jun 2002). "PDZ domain-mediated interaction of rabbit podocalyxin and Na(+)/H(+) exchange regulatory factor-2". American Journal of Physiology. Renal Physiology. 282 (6): F1129–39. doi:10.1152/ajprenal.00131.2001. PMID 11997330.

Further reading

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